TOP2A
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Official Full Name
topoisomerase (DNA) II alpha 170kDa -
Overview
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. -
Synonyms
TOP2A;topoisomerase (DNA) II alpha 170kDa;TOP2, topoisomerase (DNA) II alpha (170kD);DNA topoisomerase 2-alpha;DNA gyrase;DNA topoisomerase II, 170 kD;DNA topoisomerase (ATP-hydrolyzing);DNA topoisomerase II, alpha isozyme;TOP2;TP2A
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Chicken
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&T7
- Avi&Fc&His
Involved Pathway
TOP2A involved in several pathways and played different roles in them. We selected most pathways TOP2A participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RB in Cancer | ANLN,HLTF,RBP1,RABIF,PRMT2,HMGB2,DCK,FAF1,SMARCA2 |
| Gastric cancer network 1 | RNF216,S100P,ACTL6A,SMOC2,GATS,LIN9,MYBL2,ESM1,TPX2,C21orf33 |
| Gastric cancer network 2 | MTDH,S100A6,CHTF8,ATAD2,DSCC1,SNRPN,CEBPZ,SNURF,BRIX1,RNF144B |
| Integrated Pancreatic Cancer Pathway | MYT1,CD82,PPP1R13L,JUND,IL11,LEFTY1,FST,TFF1,WRN,AGA |
| Mitotic G1-G1/S phases | LIN37,LIN52,MYCA,MYBL2,LIN9,DYRK1A,LIN54 |
| G0 and Early G1 | E2F4,MYBL2,LIN37,LIN9,PIANP,LIN54,DYRK1A,LIN52 |
| Cell cycle | AURKB,ORC4L,HDAC1,GADD45AB,SGOL2,ENSAA,CDKN1B,YWHAE1,NCAPH,CENPP |
| Cell Cycle, Mitotic | ARPP19B,MAPRE1,HIST3H2BB,TUBG2,NEK9,TMEM188,GMNN,MAU2,CEP57,NSL1 |
Protein Function
TOP2A has several biochemical functions, for example, ATP binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP2A itself. We selected most functions TOP2A had, and list some proteins which have the same functions with TOP2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-dependent ATPase activity | SMARCAL1,TTF2,ERCC2,RAD51B,MSH5,DMC1,RAD51L3,CDK7,RAD51D,CHD8 |
| enzyme binding | HIST1H2AI,PTPLAD1,SCNM1-PS,Alb,ITGB3,YWHAE,RPA3,PPP3CA,Slc4a2,PHB |
| chromatin binding | ING2,URI1,ERG,SMARCD3,GLI2,HOXC13,MEIOB,SHMT2,AJUBA,ZMYND11 |
| DNA binding | ZNF738,HIST1H4E,HOXA9A,TCEA2,ZNF615,TOMM20A,HIST1H3A,HER12,SOX15,ZFP787 |
| DNA topoisomerase type II (ATP-hydrolyzing) activity | TOP1,TOP1L,TOP2B,TOP1MT |
| protein homodimerization activity | GPD1,PDGFA,MAP3K9,ACOT7,ACTN4,FBXO4,NAGA,ABAT,DMRTC1C2,OLIG2 |
| protein kinase C binding | TRPV4,MARCKS,GRK5,AKT1,CASQ2,PEA15A,HDAC7A,PRKCSH,TWF2,SDPR |
| protein heterodimerization activity | HIST2H2AA4,TERF1,ITGA3,HOMER1,FLOT1,BARD1,BAXA,BHLHE40,RRAGA,BDKRB2 |
| histone deacetylase binding | HIC1,HES1,HEY2,RBBP4,NUDT21,SP1,SIRT2,HDAC5,RUNX2,CRY1 |
Interacting Protein
TOP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP2A.
PRKCD;CTNNB1;ESR1;PARP1;TOP1
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References
- Jenson, EG; Baker, M; et al. MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies. PATHOLOGY RESEARCH AND PRACTICE 210:346-350(2014).
- Tykjaer Jorgensen, CL; Bjerre, C; et al. TIMP-1 and responsiveness to gemcitabine in advanced breast cancer; results from a randomized phase III trial from the Danish breast cancer cooperative group. BMC CANCER 14:-(2014).
