TOP2A

  • Official Full Name

    topoisomerase (DNA) II alpha 170kDa
  • Overview

    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
  • Synonyms

    TOP2A;topoisomerase (DNA) II alpha 170kDa;TOP2, topoisomerase (DNA) II alpha (170kD);DNA topoisomerase 2-alpha;DNA gyrase;DNA topoisomerase II, 170 kD;DNA topoisomerase (ATP-hydrolyzing);DNA topoisomerase II, alpha isozyme;TOP2;TP2A

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Rat
  • Chicken
  • Wheat Germ
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TOP2A-2611H Recombinant Human TOP2A, GST-tagged Wheat Germ Human GST
TOP2A-3351H Recombinant Human TOP2A, GST-tagged E.coli Human GST C-345aa
TOP2A-1125Z Recombinant Zebrafish TOP2A Mammalian Cells Zebrafish His
TOP2A-115H Recombinant Human TOP2A Human Non
TOP2A-17230M Recombinant Mouse TOP2A Protein Mammalian Cells Mouse His
TOP2A-199H Recombinant Human TOP2A Mammalian Cells Human His
TOP2A-6225R Recombinant Rat TOP2A Protein Mammalian Cells Rat His
TOP2A-6354C Recombinant Chicken TOP2A Mammalian Cells Chicken His
TOP2A-7701H Recombinant Human TOP2A protein, His & T7-tagged E.coli Human His&T7 Ile923~Arg1148
Top2a-7702M Recombinant Mouse Top2a protein, His & T7-tagged E.coli Mouse His&T7 Ser749~Val987
Top2a-7703R Recombinant Rat Top2a protein, His & T7-tagged E.coli Rat His&T7 Gly1079~Ser1328
TOP2A-2638H Recombinant Human TOP2A protein(1051-1240 aa), C-His-tagged E.coli Human His 1051-1240 aa
TOP2A-388H Recombinant Human TOP2A protein E.coli Human Non Ser 1354 - Ser 1473
TOP2A-4231H Recombinant Human TOP2A Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
TOP2A-4231H-B Recombinant Human TOP2A Protein Pre-coupled Magnetic Beads HEK293 Human
TOP2A-5882R Recombinant Rat TOP2A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
TOP2A-5882R-B Recombinant Rat TOP2A Protein Pre-coupled Magnetic Beads HEK293 Rat
TOP2A-6489H Recombinant Human TOP2A Protein (Ile923-Arg1148), N-His tagged E.coli Human His Ile923-Arg1148
TOP2A-9519M Recombinant Mouse TOP2A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TOP2A-9519M-B Recombinant Mouse TOP2A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TOP2A involved in several pathways and played different roles in them. We selected most pathways TOP2A participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G0 and Early G1 PIANP,MYBL2,DYRK1A,LIN37,LIN54,LIN52,LIN9,E2F4
    Cell cycle CDKN1C,YWHAE2,MLF1IP,GADD45B,TMPO,CCNA1,CLSPN,YWHAQ,PKMYT1,ABL1
    Gastric cancer network 2 PLAC8,ATAD2,CHTF8,CEBPZ,MTDH,LBR,RNF144B,RAD17,SNRPN,SNURF
    RB in Cancer HMGB2,SMARCA2,DCK,PRMT2,RBP1,RABIF,HLTF,ANLN,FAF1
    Integrated Pancreatic Cancer Pathway MST1,PPP1R13L,CST3,JUND,NOXA1,IL11,TOP1,DAXX,FKBP1B,FST
    Gastric cancer network 1 C21orf33,RNF216,SMOC2,S100P,LIN9,ACTL6A,TPX2,ECT2,MYBL2,GATS
    Mitotic G1-G1/S phases LIN52,MYCA,DYRK1A,LIN37,LIN9,MYBL2,LIN54
    Cell Cycle, Mitotic KIF20A,FOXM1,OFD1,PMF1,CNEP1R1,CP110,NCAPH2,DNA2,HAUS2,TCTN2

    Protein Function

    TOP2A has several biochemical functions, for example, ATP binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP2A itself. We selected most functions TOP2A had, and list some proteins which have the same functions with TOP2A. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity ABCG8,TAF11,SIM1,ZHX1,GABPA,RAB3GAP2,GTF2A2,H2AFV,ERBB3,SMAD2
    drug binding HTR2B,HTR2C,CHRM1,SRP54B,PDE10A,PNP,FABP1,NAMPT,CHKA,ADRB2
    enzyme binding HSPA1A,HSPA8,HSPA6,UGT1A1,ATXN10,BTG1,MDM4,EIF2AK3,CAD,CAV1
    protein binding CCL28,RBM14,CCDC22,C2orf28,NOMO2,ROPN1,SKA3,PHF16,PBX2,CTNND1
    protein homodimerization activity UGT1A6A,SEPHS1,BHLHE40,RIPK2,MYOM1,CER1,MZF1,ANXA1,DSCAML1,KLRB1B
    protein kinase C binding PEA15A,PICK1,YWHAG,PARD3,CASQ2,SQSTM1,AVPR1A,SDC4,PRKCB,PDLIM5
    DNA binding, bending TERF1,FOXD4,TOP2B,CRIP1,LEF1,FOXC1,FOXL1,SRY,HMGA2,HMGB3
    magnesium ion binding LHPP,PTENA,NLK,DOM3Z,CDC42BPB,PRPS1L1,ENO1,CLYBL,MARK2,NT5C3L
    chromatin binding CBX4,HDGF2,ANKRD17,RDBP,PRKCB,NUPR1,EGR2,BRD4,SMARCD1,APTX

    Interacting Protein

    TOP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP2A.

    PRKCD;CTNNB1;ESR1;PARP1;TOP1

    Resources

    Research Area

    Glioma Biomarkers

    References

    • Jenson, EG; Baker, M; et al. MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies. PATHOLOGY RESEARCH AND PRACTICE 210:346-350(2014).
    • Tykjaer Jorgensen, CL; Bjerre, C; et al. TIMP-1 and responsiveness to gemcitabine in advanced breast cancer; results from a randomized phase III trial from the Danish breast cancer cooperative group. BMC CANCER 14:-(2014).

    Ask a Question for All TOP2A Products

    Required fields are marked with *

    My Review for All TOP2A Products

    Required fields are marked with *