TOMM40
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Official Full Name
translocase of outer mitochondrial membrane 40 homolog (yeast) -
Overview
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is;essential for protein import into mitochondria (Humphries et al., 2005 (PubMed 15644312)). -
Synonyms
TOMM40;translocase of outer mitochondrial membrane 40 homolog (yeast);mitochondrial import receptor subunit TOM40 homolog;C19orf1;D19S1177E;PER EC1;PEREC1;TOM40;Haymaker protein;p38.5;Mitochondrial outer membrane protein;Mitochondrial outer membrane protein TOM40;Probable mitochondrial import receptor subunit TOM40 homolog;Protein Haymaker;TOM40_HUMAN;Translocase of outer membrane 40 kDa subunit homolog;Translocase of outer mitochondrial membrane 40;Translocase of outer mitochondrial membrane 40 homolog;PER-EC1
Recombinant Proteins
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- His&Fc&Avi
Involved Pathway
TOMM40 involved in several pathways and played different roles in them. We selected most pathways TOMM40 participated on our site, such as Amyotrophic lateral sclerosis (ALS),Metabolism of proteins,Mitochondrial protein import, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOMM40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitophagy | TOMM22,TOMM7,MTERFD1,TOMM20,MAP1LC3B,LC3,TOMM70A,MFN2,TOMM6,MFN1 |
| Metabolism of proteins | PAPPA,GZMH,THSD7A,PCSK2,IGFBP5B,SERP1,DNAJC24,TIMM13,SCFD1,TIMM23 |
| Amyotrophic lateral sclerosis (ALS) | DAXX,PRPH,PPP3R1,PPP3CB,TOMM40L,PPP3CC,DERL1,GRIN2D,BCL2L1,APAF1 |
| Pink/Parkin Mediated Mitophagy | TOMM7,TOMM22,MAP1LC3B,MFN2,TOMM20,MFN1,TOMM70A,MTERFD1,TOMM20B,LC3 |
| Mitochondrial protein import | MTX1,TOMM70A,GFER,GRPEL2,TIMM10,MTX2,SAMM50,TOMM6,SLC25A13,PAM16 |
Protein Function
TOMM40 has several biochemical functions, for example, porin activity,protein channel activity,protein transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOMM40 itself. We selected most functions TOMM40 had, and list some proteins which have the same functions with TOMM40. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein channel activity | TIMM23,MCL1,TOMM40L,TIMM22 |
| porin activity | VDAC3,VDAC2,VDAC1,TOMM40L,AQP9 |
| protein transmembrane transporter activity | TOMM7,TOMM70A,BLOC1S3,AZGP1,GPIHBP1,TOMM22 |
Interacting Protein
TOMM40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOMM40 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOMM40.
env;Dlg4;HLA-B;TOMM22;TOMM7;NOS1AP;FARS2;BAG2;ITIH1;ATP2B1;LAMA1;ATP5I;FKBP1A;IMMT;PHACTR4;SLC35F6;q8te30_human;RNF5
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