TNNI2
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Official Full Name
troponin T type 2 (cardiac) -
Overview
Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene -
Synonyms
TNNI2;troponin I type 2 (skeletal, fast);DA2B;FSSV;fsTnI;AMCD2B;troponin I, fast skeletal muscle;OTTHUMP00000014141;OTTHUMP00000014142;OTTHUMP00000014143;troponin I fast twitch 2;troponin I, skeletal, fast;troponin I, fast-twitch isoform;fast-twitch skeletal muscle troponin I;troponin I, fast-twitch skeletal muscle isoform
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- Skeletal muscle
- Mamanlian cells
- His
- Myc&DDK
- GST
- Non
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
TNNI2 involved in several pathways and played different roles in them. We selected most pathways TNNI2 participated on our site, such as Muscle contraction,Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Striated Muscle Contraction | CMLC1,TMOD2,DES,ACTA1B,TMOD3,TNNI2A.3,TNNI2B.1,ACTA1,MYBPC1,MYBPC3 |
| Muscle contraction | TNNI2B.1,TMOD2,MYBPC2,MYL12A,MYL12B,TNNI2B.2,LMOD1,MYBPC2B,TMOD3,DMD |
Protein Function
TNNI2 has several biochemical functions, for example, contributes_to actin binding,protein binding,troponin T binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI2 itself. We selected most functions TNNI2 had, and list some proteins which have the same functions with TNNI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRYBA2,PNKP,INCA1,CHMP4A,RAB6B,ALX1,CLDN7,S100A13,NAA50,EXOSC10 |
| troponin T binding | TNNC1,TNNI3,TNNT1 |
| contributes_to actin binding | TNNT3,TNNC2 |
Interacting Protein
TNNI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI2.
TRIM63;SMURF2
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