TNFRSF10A
-
Official Full Name
tumor necrosis factor receptor superfamily, member 10a -
Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] -
Synonyms
TNFRSF10A;tumor necrosis factor receptor superfamily, member 10a;DR4;APO2;CD261;TRAILR1;TRAILR-1;tumor necrosis factor receptor superfamily member 10A;TRAIL-R1;TRAIL receptor 1;death receptor 4;cytotoxic TRAIL receptor;TNF-related apoptosis-inducing ligand receptor 1;tumor necrosis factor receptor superfamily member 10a variant 2
Recombinant Proteins
- Human
- HEK293
- Human Cells
- Sf21 Cells
- CHO
- E.coli
- Mammalian Cells
- His
- Fc&His
- Fc
- Non
- Avi&His
Involved Pathway
TNFRSF10A involved in several pathways and played different roles in them. We selected most pathways TNFRSF10A participated on our site, such as Cytokine-cytokine receptor interaction,Apoptosis,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | TNFRSF10D,PIK3CB,IFNA16,PIK3R2,IL1B,IRAK4,PIK3CG,IFNA8,MYD88,IFNG |
| Apoptosis | DBNL,IRF6,BAX,RNF8,TICAM1,CASP6L1,TRP53,BCL2L1,AKT2,BCL2 |
| Natural killer cell mediated cytotoxicity | IFNA12,LCK,PPP3CA,KIR2DS2,FYN,SH2D1A,PIK3CD,FCGR3,KLRC4-KLRK1,PRF1 |
| Influenza A | MAPK13,IFNA4,PLG,Fasl,VDAC1,NXF2,CXCL8,HLA-DQA2,MAPK10,TNFRSF1A |
| Cytokine-cytokine receptor interaction | AMHR2,CSF1R,IFNL3,TNFRSF14,IL17A,PDGFB,IL11,CRFB2,BMP7B,IL-15RA |
Protein Function
TNFRSF10A has several biochemical functions, for example, TRAIL binding,death receptor activity,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF10A itself. We selected most functions TNFRSF10A had, and list some proteins which have the same functions with TNFRSF10A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | SORBS3,FIGLA,KCNA3,PITX2,CXXC5,TBP,SOST,PDX1,EP300,PSMD4 |
| tumor necrosis factor-activated receptor activity | TNFRSF1A,TNFRSF6B,TNFRSFA,TNFRSF9A,TNFRSF10B,HDR,NGFR,TNFRSF19,LTBR,CD40 |
| death receptor activity | NGFR |
| protein binding | MKI67IP,ALDH3A1,CDC23,C16orf59,KLF6,MSX2,AGR2,PIP5K1A,EXOC7,MRPS16 |
| TRAIL binding | TNFRSF10B,Tnfrsf22,TNFRSF10D,TNFRSF10C |
| protease binding | ALPI,C10orf2,SRI,TIMP2,LRP1,FAP,PEO1,ADAMTSL4,XBP1,CCBE1 |
| receptor activity | CUBN,MED30,GFRA1B,CADM4,SIGLEC7,GUCY1B3,SMAGP,TNFRSF25,ADIPOR1A,BTLA |
Interacting Protein
TNFRSF10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF10A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF10A.
CASP8;TNFSF10;ARAP1
TNFRSF10A Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsAdipocytokines
Endothelial Cell Markers
Cytokine and Growth Factor Receptors on VSMC
Death Receptor–Ligand System
TNF Receptor
Related Services
Related Products
References
