TMPO
-
Official Full Name
thymopoietin -
Overview
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
TMPO;thymopoietin;LAP2;LEM domain containing 4;LEMD4;TP;Lamina associated polypeptide 2;LAP 2;Thymopoietin isoform alpha;Thymopoietin related peptide isoform alpha;Thymopoietin related peptide isoforms beta/gamma;Thymopoietin, isoforms beta/gamma;TP alpha;TP beta/gamma;TPRP isoform alpha;TPRP isoforms beta/gamma;lamina-associated polypeptide 2;thymopoietin-related peptide isoform alpha;thymopoietin-related peptide isoforms beta/gamma;CMD1T;PRO0868
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mus musculus
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- HEK293T
- His
- HIS
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TMPO involved in several pathways and played different roles in them. We selected most pathways TMPO participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Clearance of Nuclear Envelope Membranes from Chromatin | VRK1,BANF1,LEMD3,VRK2 |
| Mitotic Metaphase and Anaphase | MLF1IP,B9D2,ANKLE2,CENPL,WAPAL,CENPI,SPC24,PDS5B,VRK1,ITGB3BP |
| Cell Cycle, Mitotic | LIN54,DSN1,ERCC6L,CNEP1R1,CEP152,MAU2,NIPBL,ESCO2,CDKN1B,CDK4 |
| Depolymerisation of the Nuclear Lamina | TMEM188,DULLARD,CTDNEP1B,LEMD3,STIL,CTDNEP1A,CNEP1R1,CTDNEP1 |
| Mitotic Anaphase | NUF2,RCC2,WAPAL,SKA1,RANGAP1B,DSN1,CENPQ,NSL1,LEMD3,KNTC1 |
| M Phase | CENPQ,CTDNEP1,CENPA,STAG2,ARPP19B,ARPP19,SMC2,ENSAA,ITGB3BP,GORASP1 |
| Initiation of Nuclear Envelope Reformation | VRK1,LEMD3,ANKLE2,VRK2 |
| Cell cycle | NUP35,ODF2,KIF2C,TINF2,CKAP5,ANAPC13,MAU2,ENSAA,WAPAL,WRAP53 |
Protein Function
TMPO has several biochemical functions, for example, DNA binding,lamin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMPO itself. We selected most functions TMPO had, and list some proteins which have the same functions with TMPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF544,THRB,HES3,TEAD1,ASXL2,TAF1A,AHR2,ZFP518A,NFIXB,NUSAP1 |
| protein binding | IP6K2,STX3,FSTL3,PKD1L3,PDE4DIP,CTAGE5,POLR3C,VAMP8,NFATC2,WAC |
| lamin binding | SUN2,BNIP3L,PPP4C,SUN1,TMEM201,LBR,TOR1AIP1,NARF,SYNE1,PLCB1 |
Interacting Protein
TMPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPO here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPO.
USP7;LMNA;LMNA;XRCC5;FYCO1;q81ye8_bacan;MED19;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;MAPK13;MED26;PTBP3;MYC;VCAM1;ARRB2;ARRB1
Resources
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References
- Bodey, B; et al. Thymic reticulo-epithelial cells: key cells of neuroendocrine regulation. EXPERT OPINION ON BIOLOGICAL THERAPY 7:939-949(2007).
- Bodey, B; Siegel, SE; et al. Restoration of the thymic cellular microenvironment following autologous bone marrow transplantation. IN VIVO 16:127-140(2002).
