TMOD2
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Official Full Name
tropomodulin 2 (neuronal) -
Overview
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
TMOD2;tropomodulin 2 (neuronal);tropomodulin-2;NTMOD;Tropomodulin 2;MGC39481;N Tmod;Neuronal tropomodulin;tropomodulin 2 neuronal;N-TMOD
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TMOD2 involved in several pathways and played different roles in them. We selected most pathways TMOD2 participated on our site, such as Muscle contraction,Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Striated Muscle Contraction | TNNI2,TNNT3B,TCAP,SMYHC2,TMEM8C,TNNI2B.2,ACTA1B,MYBPC2B,DES,TNNT3A |
| Muscle contraction | TNNI2,TNNI1B,TMOD3,TCAP,ANXA2,TMOD4,TMEM8C,TNNI2A.4,DMD,ANXA6 |
Protein Function
TMOD2 has several biochemical functions, for example, actin binding,tropomyosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMOD2 itself. We selected most functions TMOD2 had, and list some proteins which have the same functions with TMOD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tropomyosin binding | TNNT2A,LMOD1,TNNT1,LMOD2A,TMOD4,TMOD1,PYCARD,CALD1,NEBL,TMOD3 |
| actin binding | SMYHC1,FHOD3,CAPZA1A,INPPL1B,ABLIM1B,FGD4,PPP1R9B,MSRB2,MSRB1,ANLN |
Interacting Protein
TMOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMOD2.
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References
- Moroz, N; Guillaud, L; et al. Mutations changing tropomodulin affinity for tropomyosin alter neurite formation and extension. PEERJ 1:-(2013).
- Cox-Paulson, EA; Walck-Shannon, E; et al. Tropomodulin Protects alpha-Catenin-Dependent Junctional-Actin Networks under Stress during Epithelial Morphogenesis. CURRENT BIOLOGY 22:1500-1505(2012).
