TMEM27
-
Official Full Name
transmembrane protein 27 -
Overview
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013] -
Synonyms
TMEM27;transmembrane protein 27;NX17;NX-17;collectrin;kidney-specific membrane protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Human Cells
- His
- Fc
- Non
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
TMEM27 involved in several pathways and played different roles in them. We selected most pathways TMEM27 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TMEM27 has several biochemical functions, for example, metallopeptidase activity,peptidyl-dipeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM27 itself. We selected most functions TMEM27 had, and list some proteins which have the same functions with TMEM27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidyl-dipeptidase activity | ACE |
| metallopeptidase activity | ADAM20,ADAMTS13,ADAM5,Npepo,GM12824,ANPEP,PAPPA2,NAALADL1,ADAMTS15A,AMZ2 |
| protein binding | CD200,EEF1A2,DYNLL1,COA3,STAT5A,KIF2A,MAP4K4,C17orf62,FAM83A,NMRK1 |
Interacting Protein
TMEM27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMEM27 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMEM27.
RBM18
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