TMEM123
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Official Full Name
transmembrane protein 123 -
Overview
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. -
Synonyms
TMEM123;transmembrane protein 123;porimin;KCT3;pro oncosis receptor inducing membrane injury gene;Keratinocytes associated transmembrane protein 3;Pro oncosis receptor inducing membrane injury;Serine/threonine rich receptor;KCT-3;OTTHUMP00000235711;OTTHUMP00000235712;serine/threonine-rich receptor;pro-oncosis receptor inducing membrane injury;keratinocytes-associated transm;PORMIN
Recombinant Proteins
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
TMEM123 involved in several pathways and played different roles in them. We selected most pathways TMEM123 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM123 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TMEM123 has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM123 itself. We selected most functions TMEM123 had, and list some proteins which have the same functions with TMEM123. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COX4I2,KLF13,NAA10,PALLD,AP2A2,CCNE2,EXOC7,MUSK,CYSLTR1,ADRA2A |
| receptor activity | TLR3,DERL1,ITGB1B.1,Tnfrsf22,RRBP1B,MED16,RAMP3,ADIPOR1B,F2RL1,VMN1R43 |
Interacting Protein
TMEM123 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMEM123 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMEM123.
MAGEA11;q81y32_bacan;MAGEA11
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References
