TMC8
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Official Full Name
transmembrane channel-like 8 -
Overview
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. -
Synonyms
TMC8;transmembrane channel-like 8;epidermodysplasia verruciformis 2 , EVER2;transmembrane channel-like protein 8;EVIN2;epidermodysplasia verruciformis 2;epidermodysplasia verruciformis protein 2;EV2;EVER2;FLJ40668;FLJ43684;MGC40121;MGC102701
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TMC8-3749H | Recombinant Human TMC8 protein, His-tagged | E.coli | Human | His | 617-726 aa |
Involved Pathway
TMC8 involved in several pathways and played different roles in them. We selected most pathways TMC8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TMC8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TMC8 itself. We selected most functions TMC8 had, and list some proteins which have the same functions with TMC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
TMC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMC8.
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References
- Sirianant, L; Ousingsawat, J; et al. TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents. CELLULAR SIGNALLING 26:2826-2833(2014).
- Madeleine, MM; Carter, JJ; et al. Risk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants. CANCER MEDICINE 3:1440-1447(2014).
