TLR9
-
Official Full Name
toll-like receptor 9 -
Overview
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). -
Synonyms
CD 289;CD289;TLR 9;TLR9;TLR9_HUMAN;Toll like receptor 9;Toll like receptor 9 isoform A precursor;Toll like receptor 9 isoform B;Toll-like receptor 9;CD289 antigen
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Rabbit
- E.coli
- HEK293
- CHO
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- Fc
- His
- hIgG4
- GST
- T7
- Avi
Involved Pathway
TLR9 involved in several pathways and played different roles in them. We selected most pathways TLR9 participated on our site, such as Toll-like receptor signaling pathway,Chagas disease (American trypanosomiasis),African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| African trypanosomiasis | IL18,IFNG,ICAM1,IL12B,HBB-B1,PLCB4,FAS,HBB,HBA1,F2RL1 |
| Tuberculosis | MAPK11,EP300,HLA-DRB1,MAPK3,PPP3R1,TNFRSF1A,RHOA,C3,BID,NFKB1 |
| Toll-like receptor signaling pathway | TLR2,IFNB,MAP2K6,NFKBIAB,TAB2,IFNAR1,IFNA4,MAPK14A,MAPK14B,CXCL9 |
| Herpes simplex infection | IFNA13,TAP2,CLOCK,BLA,IFNA21,IFNPHI1,CUL1B,CFP,MHC2A,H2-Q10 |
| Malaria | DARC,GYPC,IFNG,SDC2,TLR4,ITGAL,MYD88,GYPA,Ccl12,CSF3 |
| Measles | CD3G,HSPA8,MX1,IFNA4,IFNA5,Cd209g,TNFRSF10B,SH2D1A,STAT5B,CD3D |
| Chagas disease (American trypanosomiasis) | MAPK12,MAPK8,CALR,GNAS,TGFB1,TLR2,MAPK9,C1QA,TNF,FADD |
Protein Function
TLR9 has several biochemical functions, for example, interleukin-1 receptor binding,siRNA binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR9 itself. We selected most functions TLR9 had, and list some proteins which have the same functions with TLR9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| siRNA binding | AGO2,DICER1,TARBP2,MECP2,TLR7 |
| interleukin-1 receptor binding | IL1B,IL36G,IRAK1,IL1F10,IRAK4,IL1RAP,IL36RN,IL36A,Il1f6,IL1A |
| transmembrane signaling receptor activity | CD72,GABRQ,GPR113,TLR1,PTH1RA,GHRHRL,FZD7B,LAG3,ADCYAP1R1A,CD300C |
Interacting Protein
TLR9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR9 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR9.
NCK1;CLGN;TRAF3;STK11IP;TOLLIP;UNC93B1;UGGT1;PALD1
Resources
Research Area
NeuroinflammationImmune Regulatory Molecules on Endothelial Cells
Plasmacytoid Dendritic Cells
NOD-like Receptors and the Inflammasome
Toll-Like Receptors (TLRs)
Thymus-Independent B Cell Activation
Related Services
Related Products
References
- Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
- Chan, E; Kwak, EL; et al. Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic disease. CANCER CHEMOTHERAPY AND PHARMACOLOGY 75:701-709(2015).
