TLK2
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Official Full Name
tousled-like kinase 2 -
Overview
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. -
Synonyms
TLK2;tousled-like kinase 2;serine/threonine-protein kinase tousled-like 2;MGC44450;PKU ALPHA;serine/threonine kinase;PKU-ALPHA
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Insect Cells
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TLK2-1362H | Recombinant Human TLK2 protein(Leu397-Asn772), His&GST-tagged | Insect Cells | Human | GST&His | Leu397-Asn772 | |
| TLK2-3253H | Recombinant Human TLK2, GST-tagged | E.coli | Human | GST | 453-772aa | |
| TLK2-270H | Recombinant Human TLK2, Gly & Pro tagged | Insect Cells | Human | His | 397-772 a.a. |
|
| TLK2-30422TH | Recombinant Human TLK2 | Human | Non | 388-772 a.a. |
|
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| TLK2-446H | Recombinant Human Tousled-like Kinase 2, GST-tagged, Active | Sf9 Cells | Human | GST | 388-end a.a. |
|
| TLK2-6171Z | Recombinant Zebrafish TLK2 | Mammalian Cells | Zebrafish | His |
|
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| TLK2-001HCL | Recombinant Human TLK2 cell lysate | Insect Cells | Human | Non | 397-772 a.a. |
|
| TLK2-554HCL | Recombinant Human TLK2 cell lysate | Insect Cells | Human | Non | 397-772 a.a. |
|
| TLK2-1108H | Recombinant Human TLK2 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| TLK2-1304H | Recombinant Human TLK2 protein(Leu397-Asn772) | Insect Cells | Human | Non | Leu397-Asn772 |
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| TLK2-5589H | Recombinant Human TLK2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| TLK2-5591HF | Active Recombinant Full Length Human TLK2 Protein, GST-tagged | Sf21 Cells | Human | GST | Full L. 1-750 |
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| Tlk2-6450M | Recombinant Mouse Tlk2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
Involved Pathway
TLK2 involved in several pathways and played different roles in them. We selected most pathways TLK2 participated on our site, such as DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response | RAD1,GADD45G,CHEK2,DDB2,RAD9A,HUS1B,RAD17,GADD45A,CDK5 |
Protein Function
TLK2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLK2 itself. We selected most functions TLK2 had, and list some proteins which have the same functions with TLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMK1G,EK1,PFKM,ACTBL2,MAPK9,DHX34,CARNS1,PI4K2B,PRPF4BA,SGK2B |
| protein binding | GBA,CIRBP,DNAJC7,ICAM4,SKA3,RCHY1,NOL6,CEP63,PDE4A,NCF4 |
| protein serine/threonine kinase activity | MELK,NUAK2,ADCK5,NEK2,MAP3K8,CLK3,MAP2K5,PIM3,CAMK2A,AAK1 |
Interacting Protein
TLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLK2.
IRF4;IRF7;ASF1B;RPS6KA1
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References
- Shanmugam, PST; Dayton, RD; et al. Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-Induced Xerostomia. HUMAN GENE THERAPY 24:604-612(2013).
- Garrote, AM; Redondo, P; et al. Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 70:354-357(2014).
