TLE3
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Official Full Name
transducin-like enhancer of split 3, homolog of Drosophila E(spl) -
Synonyms
ESG;Grg3a;Grg3b;mKIAA1547;2610103N05Rik
Recombinant Proteins
- Human
- Mouse
- Rat
- Sf9 Cells
- Mammalian Cells
- E.coli
- HEK293
- Flag
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TLE3-091H | Recombinant Human TLE3 Protein, DDK-tagged | Sf9 Cells | Human | Flag |
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| TLE3-16814M | Recombinant Mouse TLE3 Protein | Mammalian Cells | Mouse | His |
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| TLE3-486H | Recombinant Human TLE3 protein, GST-tagged | E.coli | Human | GST | Ser484-Tyr772 |
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| TLE3-6083R | Recombinant Rat TLE3 Protein | Mammalian Cells | Rat | His |
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| TLE3-1784HCL | Recombinant Human TLE3 cell lysate | Human | Non |
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| TLE3-5740R | Recombinant Rat TLE3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TLE3-5740R-B | Recombinant Rat TLE3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TLE3-9232M | Recombinant Mouse TLE3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TLE3-9232M-B | Recombinant Mouse TLE3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TLE3 involved in several pathways and played different roles in them. We selected most pathways TLE3 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex,Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | NMBB,ARHGAP23,RHOT1,DRAP1,PNOCB,SOUL4,RBBP5,XK,SKI,ARHGAP22 |
| Repression of WNT target genes | TLE2,AES,TLE3B,TLE4 |
| Signaling by NOTCH | RAB6A,DLK1,TLE4,MDKA,MDK,HEYL,TLE2,MDKB,DNER,DTX2 |
| Deactivation of the beta-catenin transactivating complex | CBY1,SRY,SOX13,BCL9L,PYGO1,SOX6,ASH2L,RBBP5,PYGO2,TLE2 |
| Formation of the beta-catenin:TCF transactivating complex | RBBP5,CDC73,BCL9,H3F3D,LEO1,SMARCA4,H3F3B.1,ASH2L,TLE3B,TLE1 |
| Degradation of beta-catenin by the destruction complex | CTBP2,TLE1,CTBP1,TLE2,FAM123B,TLE3B,TLE4,AES |
| Signaling by NOTCH1 | DLK1,HEYL,DNER,DTX2 |
| NOTCH1 Intracellular Domain Regulates Transcription | TUBB3,TLE4,HEY2,TLE2,HEYL,TLE1,HEY1 |
Protein Function
TLE3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE3 itself. We selected most functions TLE3 had, and list some proteins which have the same functions with TLE3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LAIR2,SMCR7,Ar,BRSK1,RPL10,CDKN2D,TGFB2,SPAST,HIST1H3C,DPEP1 |
Interacting Protein
TLE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE3.
lnx2b;AES;HDAC1;tcf7l1a;q81qn9_bacan;q81qv1_bacan;ANXA1;CUL4B;NLK
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References
- Laing, AF; Lowell, S; et al. Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression. DEVELOPMENTAL BIOLOGY 397:56-66(2015).
- Ortega, FJ; Serrano, M; et al. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR gamma gene expression. JOURNAL OF MOLECULAR MEDICINE-JMM 93:83-92(2015).
