TK2

  • Official Full Name

    thymidine kinase 2, mitochondrial

  • Overview

    This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants.

  • Synonyms

    TK2;thymidine kinase 2, mitochondrial;mt-TK;MTTK;MTDPS2

Recombinant Proteins

  • Cynomolgus
  • Human
  • Chicken
  • Zebrafish
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TK2-1026C Recombinant Cynomolgus TK2 Protein, His-tagged Mammalian Cells Cynomolgus His
TK2-1350H Recombinant Human Thymidine Kinase 2, Mitochondrial, His-tagged E.coli Human His 34-265aa
TK2-3107C Recombinant Chicken TK2 Mammalian Cells Chicken His
TK2-839Z Recombinant Zebrafish TK2 Mammalian Cells Zebrafish His
TK2-914H Recombinant Human TK2 Protein, His-tagged E.coli Human His
TK2-3586H Recombinant Human TK2 protein, His&Myc-tagged E.coli Human His&Myc 34-265aa
TK2-769C Recombinant Cynomolgus Monkey TK2 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
TK2-769C-B Recombinant Cynomolgus Monkey TK2 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    TK2 involved in several pathways and played different roles in them. We selected most pathways TK2 participated on our site, such as Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pyrimidine metabolism NME2,DHODH,POLR1E,NT5C3B,NT5C1BA,POLA2,POLR2D,DCK,PNP5A,PROZA
    Metabolic pathways DHFRL1,FBP1A,ALPPL2,B3GALT1,UROD,TWISTNB,DNMT3AB,TBXAS1,PAH,SPRA
    Drug metabolism - other enzymes UCK1,IMPDH1,UGT1A3,UCK2B,CES1C,TPMT.1,Nat3,UGT2A2,IMPDH1A,UGT1A4

    Protein Function

    TK2 has several biochemical functions, for example, ATP binding,deoxycytidine kinase activity,thymidine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TK2 itself. We selected most functions TK2 had, and list some proteins which have the same functions with TK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding KIF11,GSG2,NLK,MARS,GAK,ACTR3,CAMK2D2,TTLL12,ACOT12,RPS6KA5
    deoxycytidine kinase activity DCK
    thymidine kinase activity TK1

    Interacting Protein

    TK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TK2.

    Resources

    References

    • Sun, R; Eriksson, S; et al. Oxidative Stress Induced S-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2. JOURNAL OF BIOLOGICAL CHEMISTRY 287:24304-24312(2012).
    • Aufderklamm, S; Todenhofer, T; et al. Thymidine kinase and cancer monitoring. CANCER LETTERS 316:6-10(2012).

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