TJP2
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Official Full Name
tight junction protein 2 (zona occludens 2) -
Overview
Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane protein -
Synonyms
TJP2;tight junction protein 2 (zona occludens 2);deafness, autosomal dominant 51 , DFNA51;tight junction protein ZO-2;Friedreich ataxia region gene X104 (tight junction protein ZO 2);X104;ZO 2;ZO2;zonula occludens protein 2;Friedreich ataxia regi
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TJP2-3246H | Recombinant Human TJP2, His-tagged | E.coli | Human | His | N-term-289aa | |
| TJP2-6480C | Recombinant Chicken TJP2 | Mammalian Cells | Chicken | His |
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| TJP2-1055HCL | Recombinant Human TJP2 293 Cell Lysate | HEK293 | Human | Non |
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| TJP2-2188HFL | Recombinant Full Length Human TJP2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| TJP2-2198H | Recombinant Human TJP2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| TJP2-2198H-B | Recombinant Human TJP2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Tjp2-6441M | Recombinant Mouse Tjp2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| TJP2-6700H | Recombinant Human TJP2 Protein (Gly307-Ala669), N-His tagged | E.coli | Human | His | Gly307-Ala669 |
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Involved Pathway
TJP2 involved in several pathways and played different roles in them. We selected most pathways TJP2 participated on our site, such as Tight junction,Vibrio cholerae infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TJP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vibrio cholerae infection | ATP6V0C,ATP6V1C1,ATP6V0A1,ATP6V1D,ATP6V0E1,KDELR2,ATP6AP1,ACTG1,PRKACA,ATP6V1B1 |
| Tight junction | ACTB1,F11R.1,RHOAD,SHROOM1,CLDN14,CTNNA3,AKT1,PRKCG,MYH1A,MYH6 |
Protein Function
TJP2 has several biochemical functions, for example, guanylate kinase activity,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TJP2 itself. We selected most functions TJP2 had, and list some proteins which have the same functions with TJP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | PLEKHB1,TAX1BP3,SAE1,SNX17,PQBP1,PRKAA1,CSK,NEIL1,TBL1X,VGLL3 |
| protein domain specific binding | NLRP1,FOXA2,NCK1,YWHAE2,CNTLN,ARL1,ZNF521,PRKAR2B,DVL2,DYNLL1 |
| guanylate kinase activity | GUK1,DLG3,GUK1A,MPP3,DLG4,GUK1B,DLG4B,MPP2,DLG2,MPP1 |
| protein binding | SEPT6,GPI1,FBXW5,NUP153,MPL,NR0B2,COLGALT2,HAPLN2,TNNI1,ANKFY1 |
| protein binding, bridging | NCK1,FRMD4A,CSTA,NUFIP1,CUX1,CNKSR1,FSCN2B,SPRR1A,EVPL,BFAR |
Interacting Protein
TJP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TJP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TJP2.
SCRIB;LASP1;YWHAB;YWHAG;YWHAZ
TJP2 Related Signal Pathway
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References
- Wang, HG; Dong, JN; et al. Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis. IMMUNOLOGY 144:254-262(2015).
- Ye, P; Yu, H; et al. Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to affected periodontal tissues. JOURNAL OF PERIODONTAL RESEARCH 49:253-259(2014).
