TINAG
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Official Full Name
tubulointerstitial nephritis antigen -
Overview
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowmans capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. -
Synonyms
TINAG;tubulointerstitial nephritis antigen;TIN AG;TIN-Ag;TIN1;TIN2;TINAG_HUMAN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TINAG-5307C | Recombinant Chicken TINAG | Mammalian Cell | Chicken | His |
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| TINAG-1062HCL | Recombinant Human TINAG 293 Cell Lysate | HEK293 | Human | Non |
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| TINAG-413H | Recombinant Human TINAG Protein, His-tagged | E.coli | Human | His | Met1-Pro476 |
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Involved Pathway
TINAG involved in several pathways and played different roles in them. We selected most pathways TINAG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TINAG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TINAG has several biochemical functions, for example, cysteine-type endopeptidase activity,nucleotide binding,polysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TINAG itself. We selected most functions TINAG had, and list some proteins which have the same functions with TINAG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | SEPT8B,ABCG2D,PKN1B,RAC3B,NELFE,SF3B4,TRMT2A,RAVER1,HNRPLL,cka1 |
| polysaccharide binding | VTNB,CLEC4G,AGL,C8orf84,CLEC18C,ENPP1,ENPP2,VTN,SUSD2,PRG4 |
| scavenger receptor activity | LOXL3,GM106,PRG4A,SCARF2,ACKR4,CXCL16,LGALS3BP,PRG4B,CD5,TMPRSS13B |
| cysteine-type endopeptidase activity | CASP3B,USP18,CASP10,CASP14,CTSH,CTSL1B,USP49,CASP3A,CTSB,USP12 |
Interacting Protein
TINAG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TINAG here. Most of them are supplied by our site. Hope this information will be useful for your research of TINAG.
TMEM45B;CPB2
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References
- Krishnan, N; Perazella, MA; et al. Drug-induced Acute Interstitial Nephritis Pathology, Pathogenesis, and Treatment. IRANIAN JOURNAL OF KIDNEY DISEASES 9:3-13(2015).
- Kinloch, AJ; Chang, A; et al. Vimentin Is a Dominant Target of In Situ Humoral Immunity in Human Lupus Tubulointerstitial Nephritis. ARTHRITIS & RHEUMATOLOGY 66:3359-3370(2014).
