TICAM1
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Official Full Name
toll-like receptor adaptor molecule 1 -
Overview
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering -
Synonyms
TICAM1;toll-like receptor adaptor molecule 1;TIR domain-containing adapter molecule 1;MGC35334;PRVTIRB;TICAM 1;TRIF;putative NF-kappa-B-activating protein 502H;TIR domain containing adaptor inducing interferon-beta;TIR domain-containing adapter p
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
TICAM1 involved in several pathways and played different roles in them. We selected most pathways TICAM1 participated on our site, such as Activated TLR4 signalling,Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Caspase activation via extrinsic apoptotic signalig pathway | DCC,RNF8,DAPK3,CASP8L1,DAPK1 |
| Cytosolic sensors of pathogen-associated DNA | POLR3H,TREX1,POLR3F,DHX9,SAA1,IFI16,TRIM56,NLRP4C,ALCAMB,RIPK3 |
| Diseases associated with the TLR signaling cascade | TIRAP,TLR6,TLR10 |
| Chagas disease (American trypanosomiasis) | MYD88,TGFB1,CCL3L1,GNA15,PIK3R3,IFNGR1,CD247,TNF,GNA14,PLCB2 |
| Activated TLR4 signalling | MAPKAPK2B,MAPK14,DUSP3B,NOD1,ATF2,TNIP2,PELI3,S100B,APPB,ALCAMB |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | TANK |
| Disease | CCR5,COBRA1,PSTPIP2,FKBP1A,FDX1L,GPC6,PPIA,TCEA1,GYG2,RBP1 |
| Apoptosis | PLEC,PPP3R1B,PPP3R1,DSP,BAD,RIPK1L,PLECA,DNM1L,PRKACBB,CRADD |
Protein Function
TICAM1 has several biochemical functions, for example, protein binding,protein kinase binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TICAM1 itself. We selected most functions TICAM1 had, and list some proteins which have the same functions with TICAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | OLFR958,MRGPRB3,IL10RA,OLFR491,IKBKG,GPR124,OLFR488,LPAR6A,GNA11A,SHC3 |
| protein kinase binding | NR4A3,CACNB4,NIPAL1,TRAF6,MAG,ELP2,TCTN2,KCNA5,CCNE2,TRIM22 |
| protein binding | ARID1A,GSN,PLEK,TMEM79,HSF1,ADRA2A,UBE2I,VPS36,GP1BA,EHD4 |
Interacting Protein
TICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TICAM1.
TBK1;TNFAIP3;TICAM2;PIAS4;SRSF4;KIF21B;Immt;TANK;CDCA5;CEP170P1;MKNK2
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