TGIF2
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Official Full Name
TGFB-induced factor homeobox 2 -
Overview
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. -
Synonyms
TGIF2;TGFB-induced factor homeobox 2;TGFB induced factor 2 (TALE family homeobox);homeobox protein TGIF2;5 TG 3 interacting factor 2;TGF (beta) induced transcription factor 2;TGFB induced factor 2;Transforming growth factor beta inducedfactor 2;OTTHUMP00000030848;OTTHUMP00000030849;5-TG-3 interacting factor 2;TGF-beta-induced transcription factor 2;TGF(beta)-induced transcription factor 2;TGFB-induced factor 2 (TALE family homeobox);transcription growth factor-beta-induced
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TGIF2-4690R | Recombinant Rhesus monkey TGIF2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| TGIF2-1113HCL | Recombinant Human TGIF2 293 Cell Lysate | HEK293 | Human | Non |
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| TGIF2-2401H | Recombinant Human TGIF2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| TGIF2-4504R | Recombinant Rhesus Macaque TGIF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TGIF2-4504R-B | Recombinant Rhesus Macaque TGIF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
TGIF2 involved in several pathways and played different roles in them. We selected most pathways TGIF2 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGIF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | ACVR1BA,TGFBR1,SKP1,LEFTY1,RBL1,ID1,LFT2,LFT1,ID4,BMPR1A |
Protein Function
TGIF2 has several biochemical functions, for example, DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGIF2 itself. We selected most functions TGIF2 had, and list some proteins which have the same functions with TGIF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | CIR1,TBX18,FOXO3,MLXIPL,ZNF92,PRDM1A,ZNF606,TBX1,HLFB,TFCP2 |
| DNA binding | PRDM4,NKX6.3,CARF,HOXB1,ZNF554,MCM3AP,TAF9,MBD1B,ZNF581,PRDM2 |
Interacting Protein
TGIF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGIF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGIF2.
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