TDG
-
Official Full Name
thymine-DNA glycosylase -
Synonyms
TDG;thymine-DNA glycosylase;G/T mismatch-specific thymine DNA glycosylase;EC 3.2.2.29;003211
Recombinant Proteins
- Human
- Chicken
- M.Thermoautotrophicus
- Methanothermobacter thermautotrophicus
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Insect Cells
- His
- Non
- SUMO
- Flag
- Avi
- Fc
Involved Pathway
TDG involved in several pathways and played different roles in them. We selected most pathways TDG participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | OGG1,LIG3,POLE,NEIL2,POLB,POLD1,APEX2,PARP3,PCNA,POLD3 |
Protein Function
TDG has several biochemical functions, for example, DNA N-glycosylase activity,RNA polymerase II transcription cofactor activity,SUMO binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDG itself. We selected most functions TDG had, and list some proteins which have the same functions with TDG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | XRCC2,MTERF3,DMC1,SP8B,HLF,CTNNB1,ZNF638,IFI16,RAD51B,TARDBP |
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | MBD4,TDG.1 |
| mismatched DNA binding | MSH4,MLH3,MSH5,MSH6,PMS1,MLH1 |
| protein binding | CDC27,ZKSCAN17,EIF4G1,TBCA,PDCD5,POLE3,ARL4A,LPHN1,PARP1,XIAP |
| damaged DNA binding | PCNA,POLI,POLK,XRCC6,TRP53,XRCC1,TP63,OGG1,CRY-DASH,TP53 |
| uracil DNA N-glycosylase activity | SMUG1,TDG.1,APEX1,CCNO,UNG,UNGA |
| SUMO binding | HERC2,USPL1,PML,TOLLIP,RPS3,CBX4,USP25 |
| DNA N-glycosylase activity | SMUG1,NTHL1,OGG1,NEIL3,NEIL1 |
| protein homodimerization activity | MAPK4,TFAP2A,PGCP,SRGAP2,CD226,CPNE1,TBC1D22A,MLL1,SYT14,BOKB |
Interacting Protein
TDG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDG here. Most of them are supplied by our site. Hope this information will be useful for your research of TDG.
AICDA;GADD45A;JUNB;SKIL;STAT3;CRK;SUMO1;IKZF1;SMAD4;DDX39B;SETX;SNIP1
Resources
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References
- Thwe-Thwe-Win; Hirao, T; et al. Current genetic structure of teak (Tectona qrandis) in Myanmar based on newly developed chloroplast single nucleotide polymorphism and nuclear single sequence repeat markers. TROPICAL CONSERVATION SCIENCE 8:235-256(2015).
- McLeod, HC; Roy, JW; et al. Patterns of Entrapped Air Dissolution in a Two-Dimensional Pilot-Scale Synthetic Aquifer. GROUNDWATER 53:271-281(2015).
