TCL1A
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Official Full Name
T-cell leukemia/lymphoma 1A -
Overview
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] -
Synonyms
TCL1A;T-cell leukemia/lymphoma 1A;TCL1;T-cell leukemia/lymphoma protein 1A;oncogene TCL1;oncogene TCL-1;protein p14 TCL1;T-cell lymphoma-1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- HEK293T
- GST
- Non
- T7
- His
- Myc&DDK
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCL1A-3160H | Recombinant Human TCL1A, GST-tagged | E.coli | Human | GST | 1-114 | |
| TCL1A-1404H | Recombinant Human T-cell Leukemia/lymphoma 1A | E.coli | Human | Non |
|
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| TCL1A-2903H | Recombinant Human TCL1A, T7-tagged | E.coli | Human | T7 | 1-114 a.a. |
|
| TCL1A-30569TH | Recombinant Human TCL1A | E.coli | Human | Non | Full L. 1-114 a.a. |
|
| TCL1A-7041H | Recombinant Human TCL1A, His tagged | E.coli | Human | His | Ala 2-Asp 114 |
|
| TCL1A-1174HCL | Recombinant Human TCL1A 293 Cell Lysate | HEK293 | Human | Non |
|
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| TCL1A-1194H | Recombinant Human TCL1A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Tcl1a-2119R | Recombinant Rat Tcl1a Protein, His-tagged | E.coli | Rat | His | Ala6-Glu112 |
|
| TCL1A-6613H | Recombinant Human TCL1A Protein (Met1-Asp114), N-His tagged | E.coli | Human | His | Met1-Asp114 |
|
| Tcl1a-743M | Recombinant Mouse Tcl1a protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 1-116a.a. |
|
Involved Pathway
TCL1A involved in several pathways and played different roles in them. We selected most pathways TCL1A participated on our site, such as PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCL1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | LAMC1,IL2RG,HGF,LPAR3,PPP2R2D,ITGAV,GNG11,TCL1B4,IFNAR1,GNGT1 |
Protein Function
TCL1A has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCL1A itself. We selected most functions TCL1A had, and list some proteins which have the same functions with TCL1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C19orf46,UHRF2,PTGES3,DTX3L,USP42,DHX32,NACA,TXNDC5,AGXT2L2,GRASP |
Interacting Protein
TCL1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCL1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TCL1A.
CALCOCO2;CADPS;AKT1;CEP55;WDR47;TCF4
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