TCF7

  • Official Full Name

    transcription factor 7 (T-cell specific, HMG-box)

  • Overview

    The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    TCF7;transcription factor 7 (T-cell specific, HMG-box);transcription factor 7;TCF 1;T-cell-specific transcription factor 1;TCF-1;FLJ36364;MGC47735

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Chicken
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • His
  • Non
  • GST
  • N-His&C-Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TCF7-3159H Recombinant Human TCF7, His-tagged E.coli Human His 1-384aa
TCF7-16564M Recombinant Mouse TCF7 Protein Mammalian Cells Mouse His
TCF7-2043Z Recombinant Zebrafish TCF7 Mammalian Cells Zebrafish His
TCF7-6116C Recombinant Chicken TCF7 Mammalian Cells Chicken His
TCF7-1753HCL Recombinant Human TCF7 cell lysate Human Non
TCF7-119H Recombinant Human TCF7 Protein, His-tagged E.coli Human His
TCF7-120M Recombinant Mouse TCF7 Protein, His-tagged E.coli Mouse His
TCF7-15H Recombinant Human TCF7 Protein, GST-tagged Wheat Germ Human GST
TCF7-4921H Recombinant Human TCF7 protein(1-384aa), His&Myc-tagged E.coli Human N-His&C-Myc 1-384aa
TCF7-6778HF Recombinant Full Length Human TCF7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 384 amino acids
TCF7-9082M Recombinant Mouse TCF7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TCF7-9082M-B Recombinant Mouse TCF7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TCF7 involved in several pathways and played different roles in them. We selected most pathways TCF7 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal cell carcinoma TP53,FZD6,GLI3,SETD6,FZD10,HHIP,Fzd4,WNT9A,WNT5A,WNT16
    Endometrial cancer ERBB2,PIK3CG,BRAF,MLH1,CASP9,ARAF,AXIN1,AXIN2,CTNNA2,FOXO3
    Colorectal cancer TGFB1,AKT2,MAPK8,PIK3CD,BCL2,TP53,PIK3R3,Casp3,SMAD4,MAPK3
    Acute myeloid leukemia MAPK3,PIM1,MAP2K1,PIK3CG,IKBKB,BAD,BRAF,STAT5A,PIK3R2,SPI1
    Thyroid cancer CCDC6,PAX8,TFG,TPR,KRAS,MAPK3,RXRA,MAP2K1,LEF1,CDH1
    Pathways in cancer FGF19,PLCB3,Fasl,AXIN2,NOS2,BCR,PPARG,Adcy4,MSH3,ITGA6
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA1,CACNG1,CACNA2D1,DES,ITGAV,CTNNA1,JUP,ITGA2,SGCA,TCF7L2
    Melanogenesis MAP2K2,MAP2K2A,MC1R,GSK3B,WNT6,CAMK2B,MAP2K1,PRKCBA,HRASA,GNA15.4
    Hippo signaling pathway ID1,DVL3,TEAD3,PPP2R2C,BMPR1A,RASSF1,YWHAZ,BMP5,ITGB2,BBC3

    Protein Function

    TCF7 has several biochemical functions, for example, beta-catenin binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7 itself. We selected most functions TCF7 had, and list some proteins which have the same functions with TCF7. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZFAND5,SNX9,PURA,AGTR2,C14orf135,CTCF,RTKN,FYB,CORO2B,YWHAZ
    transcription factor activity, sequence-specific DNA binding EOMES,ZBTB17,SREBF1,FOXP4,ZSCAN4D,MLXIPL,L3MBTL4,ZBTB14,ELF2A,SALL3B
    chromatin binding CITED1,KDM1A,HOXC13,EZH1,PARP1,TP53,BARX2,MNT,ANKRD2,MECP2
    transcription regulatory region DNA binding Arid4b,ATF3,KLF15,KLF2A,NFKB1,XRCC5,TP63,SNCA,ATF4,BCL11AA
    beta-catenin binding SOX9,TCF7L1B,CDH24,SHROOM2,LEF1,MED12L,TCF7L2,SALL1,SMAD7,EP300
    sequence-specific DNA binding LHX8A,GCM2,JUNBB,NR1D2B,DLX2B,VENTX,ZNF498,FOXJ1A,ATF4B2,HOXD11A

    Interacting Protein

    TCF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7.

    CTNNB1;BCR;RUNX3

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