TCF12

  • Official Full Name

    transcription factor 12

  • Overview

    The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

  • Synonyms

    TCF12;transcription factor 12;bHLHb20;HEB;helix loop helix transcription factor 4;HsT17266;HTF4;TCF-12;E-box-binding protein;DNA-binding protein HTF4;transcription factor HTF-4;helix-loop-helix transcription factor 4;class B basic helix-loop-h

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TCF12-3157H Recombinant Human TCF12, His-tagged E.coli Human His 358-706aa
TCF12-12825Z Recombinant Zebrafish TCF12 Mammalian Cells Zebrafish His
TCF12-582H Recombinant Human TCF12 Protein, His-tagged E.coli Human His
TCF12-5988R Recombinant Rat TCF12 Protein Mammalian Cells Rat His
TCF12-6927C Recombinant Chicken TCF12 Mammalian Cells Chicken His
TCF12-1183HCL Recombinant Human TCF12 293 Cell Lysate HEK293 Human Non
TCF12-33H Recombinant Human TCF12 protein, His-tagged E.coli Human His Gly511-Glu660
TCF12-5647R Recombinant Rat TCF12 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
TCF12-5647R-B Recombinant Rat TCF12 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    TCF12 involved in several pathways and played different roles in them. We selected most pathways TCF12 participated on our site, such as CDO in myogenesis,Developmental Biology,Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Id Signaling Pathway ELK3,MYOD1,MYOG,KDR,PAX2,MYF6,ACVRL1,IFI16,MSC,TCF3B
    Myogenesis MYOD1,CDH4,BNIP2,MYF6,MYOG,BOC,TCF3A,MEF2B,TCF4,TCF3B
    Developmental Biology NADL1.1,JAK3,EPHB3A,HFE2,MARK3,COL9A1A,ITGB3A,COL9A1,CRMP1,NRP2
    CDO in myogenesis BNIP2,CDH4,MEF2AA,CDON,CTNNA1,CDH2,MYF6,MYOG,MYOD1,BOC

    Protein Function

    TCF12 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,SMAD binding,bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF12 itself. We selected most functions TCF12 had, and list some proteins which have the same functions with TCF12. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TP63,IRF4,NR6A1,NCOA3,ONECUTL,CEBPZ,PBX1,HNF1A,OTX1,AKNA
    protein heterodimerization activity ITGA3,H2AFVA,HIST1H3H,SNX5,ANO9A,ODZ4,TGFB2,CYBA,ATF2,H2AFJ
    bHLH transcription factor binding PSMD9,SMAD3,FOXH1,SOX9,TCF3,MAP3K10,TCF21,HAND1,LMO2,SP1
    protein homodimerization activity RABEP1,MIXL1,GRPEL2,BHLHE40,GNB2L1,DGAT2,TERF2,RNF17,CLIC6,HSPB6
    protein binding RPL11,WDTC1,DTX3L,UBOX5,Tnfrsf22,SUMO2,FH,PRPF31,TRIP6,VBP1
    SMAD binding ACVR1B,COL1A2,BMP2,MAGI2,SMAD2,FKBP1A,PURA,SKIA,EP300,MEF2A
    enhancer binding SOX9,ARNT,MESP1,TIPARP,ELL3,FOXH1,RAI1,AHR,TCF3,SMAD2
    contributes_to transcription regulatory region DNA binding NFYB,ATF4,NFYC,TCF3,NR1H3,HAND1,TAF1,NFYA,HDAC4,HDAC5
    transcription factor activity, sequence-specific DNA binding JUNBB,EOMESA,ZSCAN16,ZFP36L1,IKZF4,BACH2,MEF2A,CNOT8,ELK4,SMAD9

    Interacting Protein

    TCF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF12.

    HEXIM2;MAPKBP1;CRCP;STK16;PSMA1;SRI;STAT5A

    Resources

    Research Area

    Neural Stem Cell Transcription Factors
    T Cell Antigen Recognition
    B Cell Transcription Factors

    References

    • di Rocco, F; Baujat, G; et al. Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations. EUROPEAN JOURNAL OF HUMAN GENETICS 22:1413-1416(2014).
    • Wang, P; Cui, J; et al. Differential expression of microRNAs in 2-cell and 4-cell mouse embryos. ZYGOTE 22:455-461(2014).

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