TCEB3
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Official Full Name
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -
Overview
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. -
Synonyms
TCEB3;transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A);transcription elongation factor B (SIII), polypeptide 3 (110kD, elongin A);transcription elongation factor B polypeptide 3;SIII;TCEB3A;Ela1;Elo A;EloA;ELOA1_HUMAN;Elongin 110 kDa subunit;Elongin-A;ElonginA;RNA polymerase II transcription factor SIII subunit A1;SIII p110;TCEB 3;Transcription elongation factor B (SIII) polypeptide 3 (110kD);Transcription elongation factor B (SIII) polypeptide 3;Transcription elongation factor B alpha subunit;OTTHUMP00000002990
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCEB3-3797H | Recombinant Human TCEB3 protein, His-tagged | E.coli | Human | His | 1-400 aa | |
| TCEB3-10472Z | Recombinant Zebrafish TCEB3 | Mammalian Cells | Zebrafish | His |
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| TCEB3-16552M | Recombinant Mouse TCEB3 Protein | Mammalian Cells | Mouse | His |
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| TCEB3-2594C | Recombinant Chicken TCEB3 | Mammalian Cells | Chicken | His |
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| TCEB3-1751HCL | Recombinant Human TCEB3 cell lysate | Human | Non |
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| TCEB3-9076M | Recombinant Mouse TCEB3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TCEB3-9076M-B | Recombinant Mouse TCEB3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TCEB3 involved in several pathways and played different roles in them. We selected most pathways TCEB3 participated on our site, such as Disease,Formation of HIV elongation complex in the absence of HIV Tat,Formation of HIV-1 elongation complex containing HIV-1 Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCEB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | CFTR,PSTPIP2,OPN1LW,RDBP,PPIA,SSRP1,FDX1,CHMP4B,CPSF6,PPIAL4A |
| HIV Life Cycle | RCC1,ELL,NMT2,PDCD6IP,CDK9,PSTPIP2,CHMP4C,SSRP1,NMT1,VPS37A |
| HIV Transcription Elongation | SSRP1 |
| Formation of HIV elongation complex in the absence of HIV Tat | TCEA1,COBRA1,WHSC2,SUPT4H1,RDBP,TH1L,ELL,SSRP1,CTDP1,SUPT5H |
| Gene Expression | EIF5,ZNF263,ZNF561,CBX3A,ZNF75A,TBX5,CRCP,SNRNP48,ZNF37A,ZNF133 |
| Formation of RNA Pol II elongation complex | CDK9,PSTPIP2,CCNT2B,NELFE,CTDP1,TH1L,SSRP1A,SUPT16H,TCEA1,ELL |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | ELL,RDBP,TCEA1,SUPT4H1,WHSC2,COBRA1,CDK9,TH1L,SUPT5H,CTDP1 |
| HIV Infection | APOBEC3G,AP1B1,SSRP1,NMT2,CHMP4C,AP1G1,ELL,RCC1,NPM1,TAF1L |
Protein Function
TCEB3 has several biochemical functions, for example, DNA binding,protein binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCEB3 itself. We selected most functions TCEB3 had, and list some proteins which have the same functions with TCEB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | KBTBD5,CUL3,KLHL14,KBTBD10,KLHL32,TCEB1A,KLHL42,KLHL31,ANAPC11,RNF40 |
| DNA binding | POLR3H,CARHSP1,ZNF239,CTC1,ABL1,HES7,TBX5B,ARX,HIST1H2B7,EXO5 |
| protein binding | COMP,ATP2B1,CREB3L1,RTKN,DESI1,IFRD2,MAPK4,MTF1,YTHDF3,VEGFC |
Interacting Protein
TCEB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCEB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCEB3.
PLK4;FLJ13057;KRT40;HOMEZ;CEP57L1;FAM9B
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