TBL1X

  • Official Full Name

    transducin (beta)-like 1X-linked

  • Overview

    The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

  • Synonyms

    TBL1X;transducin (beta)-like 1X-linked;TBL1, transducin (beta) like 1;F-box-like/WD repeat-containing protein TBL1X;EBI;transducin beta-like protein 1X;transducin-beta-like protein 1, X-linked;TBL1;SMAP55

Recombinant Proteins

  • Cynomolgus
  • Chicken
  • Zebrafish
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TBL1X-1004C Recombinant Cynomolgus TBL1X Protein, His-tagged Mammalian Cells Cynomolgus His
TBL1X-3951C Recombinant Chicken TBL1X Mammalian Cells Chicken His
TBL1X-5323Z Recombinant Zebrafish TBL1X Mammalian Cells Zebrafish His
TBL1X-99H Recombinant Human TBL1X protein, His-tagged E.coli Human His 592aa(including fusion tag)
TBL1X-1214HCL Recombinant Human TBL1X 293 Cell Lysate HEK293 Human Non
TBL1-118H Recombinant Human TBL1 Protein, His-tagged E.coli Human His
TBL1X-747C Recombinant Cynomolgus Monkey TBL1X Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
TBL1X-747C-B Recombinant Cynomolgus Monkey TBL1X Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    TBL1X involved in several pathways and played different roles in them. We selected most pathways TBL1X participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBL1X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway DKK1B,CACYBP,CCND3,MAPK9,SFRP1,PRKCB,PRKCA,WNT3A,PRKACG,CER1

    Protein Function

    TBL1X has several biochemical functions, for example, beta-catenin binding,histone binding,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBL1X itself. We selected most functions TBL1X had, and list some proteins which have the same functions with TBL1X. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding KEAP1B,NR0B2A,GATA6,HDAC9,ESRRB,HES4,NIF3L1,SOX8,TMEM173,ZBTB49
    protein C-terminus binding MKI67,ATXN2,CDC37,IFT52,BCL10,DST,RBFOX1,HAND2,ATP2A2,VGLL2
    beta-catenin binding LZIC,TBL1XR1,DVL3,DACT1,LEF1,CDH2,TRPC4,NUMB,PTPRJ,CTNNA3
    transcription corepressor activity NR1H4,SAP30,E2F6,YWHAB,KCNA3,PSMC3,SRSF2,NR2F2,BRD7,SSX1
    transcription regulatory region DNA binding ZNF335,SALL3B,XBP1,GABPB1,AIRE,MTERF3,NFE2L2,TFAP4,GATA5,HINFP
    protein domain specific binding HIST1H4H,TADA3,ARL1,HIST4H4,CALM2,YWHAQ,ARFIP1,MYH9,CHMP2A,ARFIP2A
    histone binding HIST1H4B,HIST1H4H,BRD7,HIST2H3C1,SART3,MCM2,AIRE,HIST1H47,HIST1H4M,DAXX
    protein binding FHL1,TGFB3,LATS1,GTF3C3,FAM207A,TBX18,CXADR,TRIM3,FSHR,CASP7

    Interacting Protein

    TBL1X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBL1X here. Most of them are supplied by our site. Hope this information will be useful for your research of TBL1X.

    HDAC3;TINF2;CTNNB1;CACYBP;DLX3;HP;TERF1;KHDRBS1;DNAJB4;HDAC7;TBL1XR1;HDAC5

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