TBCA
-
Official Full Name
tubulin folding cofactor A -
Overview
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. -
Synonyms
TBCA;tubulin folding cofactor A;tubulin specific chaperone a;tubulin-specific chaperone A;CFA;Chaperonin cofactor A;Co chaperonin associated with a & b tubulin;Cofactor A;TBCA_HUMAN;TCP1 chaperonin cofactor A;TCP1-chaperonin cofactor A;Tubulin cofactor a;Tubulin-folding cofactor A;OTTHUMP00000128368;OTTHUMP00000222303;OTTHUMP00000222304;OTTHUMP00000222362;OTTHUMP00000222437
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Human
- HEK293
- HEK293T
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TBCA involved in several pathways and played different roles in them. We selected most pathways TBCA participated on our site, such as Metabolism of proteins,Post-chaperonin tubulin folding pathway,Protein folding, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein folding | FBXW2,FBXL5,TBCE,PFDN4,PFDN5,CCT7,TBCD,PFDN1,SERPINA7,FBXW9 |
| Metabolism of proteins | SLC30A6,ARSJ,EXOC5,ADAMTSL4,GRPEL2,NAPAA,TIMM22,SSPO,TRAPPC5,PFDN6 |
| Post-chaperonin tubulin folding pathway | TBCD,TBCE,SERPINA7,TBCB,TBCC,ARL2 |
Protein Function
TBCA has several biochemical functions, for example, chaperone binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBCA itself. We selected most functions TBCA had, and list some proteins which have the same functions with TBCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | SPG7,NPM1,H2-KE2,AIPL1,HSPA9,DNAJA3,DNAJB4,SRSF10,LRPAP1,ERO1LB |
| protein binding | APLF,RSG1,PPIE,GTF2A1,DEAF1,HNRNPA1,NLRX1,NRG1,HOXB6,IFNAR2 |
| tubulin binding | ALDOA,STMN3,MTAP7D3,MTAP4,NCALD,TPR,TPPP,TTLL6,CLIP1,RABGAP1 |
| chaperone binding | VWF,DNAJA2,HSCB,DNAJB7,PFDN4,HES1,SLC25A17,GNB5,AMFR,STIP1 |
| poly(A) RNA binding | RPS27A,SF3A1,BCLAF1,ELAC2,DSP,MRPS7,ZCCHC7,EIF1AX,PRDX1,HIST1H1D |
Interacting Protein
TBCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBCA here. Most of them are supplied by our site. Hope this information will be useful for your research of TBCA.
TERF2IP;RXRB;MDM2;TAF9
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