TBC1D4
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Official Full Name
TBC1 domain family, member 4 -
Overview
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. -
Synonyms
TBC1D4;TBC1 domain family, member 4;AS160;TBC1 domain family member 4;akt substrate of 160 kDa;Acrg embryonic lethality minimal region ortholog;TBC (Tre-2, BUB2, CDC16) domain-containing protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TBC1D4-3130H | Recombinant Human TBC1D4, His-tagged | E.coli | Human | His | 1-200aa | |
| TBC1D4-16H | Recombinant Human TBC1D4, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| TBC1D4-065H | Recombinant Human TBC1 domain family, member 4 Protein, His&Flag&StrepII tagged | E.coli | Human | N-Twin strep and C-His&Flag | 29-451aa |
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| TBC1D4-1143HFL | Recombinant Full Length Human TBC1D4, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| TBC1D4-30142H | Recombinant Human TBC1D4 protein, GST-tagged | E.coli | Human | GST | Met1-Gln200 |
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| Tbc1d4-6308M | Recombinant Mouse Tbc1d4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
TBC1D4 involved in several pathways and played different roles in them. We selected most pathways TBC1D4 participated on our site, such as Thyroid hormone signaling pathway,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBC1D4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PIK3R5,MED24,ATP1A3,MTOR,PLN,NOTCH1,MAPK3,PLCG1,DIO3,PIK3CB |
| Insulin resistance | PRKAA1,GFPT2,PTPN11A,PTPN11B,OGT,NR1H3,INS2,PPARGC1A,CRTC2,SLC2A1A |
Protein Function
TBC1D4 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBC1D4 itself. We selected most functions TBC1D4 had, and list some proteins which have the same functions with TBC1D4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RGS17,ALDH1A1,ARHGAP42A,SMAP2,ARHGDIB,ABR,RINL,TBC1D3,OCRL,ARHGAP8 |
Interacting Protein
TBC1D4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBC1D4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBC1D4.
YWHAZ;DDX56;U2SURP;LAMTOR5;KIAA0556;NFAT5;NDUFA8;TET2;NAV1;TOPBP1;EP400;CDK5RAP2;KIAA1551;RBM12;FAM208A;ZMIZ1;pi3p;BMH1
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References
- Tonks, KT; Ng, Y; et al. Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects. DIABETOLOGIA 56:875-885(2013).
- Lier, N; Gresko, N; et al. Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. HISTOCHEMISTRY AND CELL BIOLOGY 138:101-112(2012).
