TAL2
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Official Full Name
T-cell acute lymphocytic leukemia 2 -
Overview
This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. -
Synonyms
TAL2;T-cell acute lymphocytic leukemia 2;T-cell acute lymphocytic leukemia protein 2;bHLHa19;Class A basic helix-loop-helix protein 19;T cell acute lymphocytic leukemia 2;T cell acute lymphocytic leukemia protein 2;TAL 2;TAL-2;TAL2_HUMAN;OTTHUMP00000021840
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAL2-11484Z | Recombinant Zebrafish TAL2 | Mammalian Cells | Zebrafish | His |
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| TAL2-4614R | Recombinant Rhesus monkey TAL2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TAL2-1258HCL | Recombinant Human TAL2 293 Cell Lysate | HEK293 | Human | Non |
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| TAL2-4430R | Recombinant Rhesus Macaque TAL2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| TAL2-4430R-B | Recombinant Rhesus Macaque TAL2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| TAL2-5159H | Recombinant Human TAL2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Tal2-6287M | Recombinant Mouse Tal2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
TAL2 involved in several pathways and played different roles in them. We selected most pathways TAL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TAL2 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAL2 itself. We selected most functions TAL2 had, and list some proteins which have the same functions with TAL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | POGZA,E2F7,ZNF583,ZBTB11,STAT4,LEF1,STOX1,NHLH2,PAX9,ATF5A |
| DNA binding | E4F1,MIER3,PTF1A,HOPX,RAD51D,IRX3B,RXRGA,SCML1,CCDC71L,MESP1 |
| protein binding | TMEM30B,TRAPPC6B,RAI2,H2-AA,DTL,KIAA1274,GCNT1,CD58,FHL3,PRSS2 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FLI1B,FOXK1,EOMESA,FOXI2,FOXD4L1,FOXO3A,SP4,MEF2A,TRP53,FOXS1 |
| protein dimerization activity | TWIST1B,HER13,NEUROD4,FIGLA,SIM1A,GRIN2A,MYCA,GGN,ID2B,HER2 |
Interacting Protein
TAL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAL2.
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References
- Lee, J; Su, EW; et al. Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways. MOLECULAR AND CELLULAR BIOLOGY 31:3963-3974(2011).
- Bamberger, M; Santos, AM; et al. A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY 286:30324-30336(2011).
