TAF15
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Official Full Name
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -
Overview
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. -
Synonyms
TAF15;TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa;TAF2N, TATA box binding protein (TBP) associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56);TATA-binding protein-associated factor 2N;hTAFII68;Npl3;RBP56;RNA binding protein 56;TAF;TAF2N;TAFII68;TAF(II)68;RBP56/CSMF fusion;TBP-associated factor 15;68 kDa TATA-binding protein-associated factor;TATA box-binding protein-associated factor 2N (RNA-binding protein 56);TATA box binding protein (TBP)-associated f
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAF15-2466H | Recombinant human TAF15, His-tagged | E.coli | Human | His | 148-406 aa |
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| TAF15-4930Z | Recombinant Zebrafish TAF15 | Mammalian Cell | Zebrafish | His |
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| TAF15-1274HCL | Recombinant Human TAF15 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
TAF15 involved in several pathways and played different roles in them. We selected most pathways TAF15 participated on our site, such as Basal transcription factors,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | GTF2H2C_2,MNAT1,GTF2B,TAF12,TAF11,GTF2IRD1,TAF7L,GTF2H4,GTF2F1,TAF7 |
| Transcriptional misregulation in cancer | LYL1,DOT1L,EYA1,IL1R2,SMAD1,RUNX1,TGFBR2,ELK4,MMP9,SSX2 |
Protein Function
TAF15 has several biochemical functions, for example, DNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF15 itself. We selected most functions TAF15 had, and list some proteins which have the same functions with TAF15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PCGF3,REXO1L1,XCL2,SFPQ,MID1,KIAA1958,FAM69A,ZBTB7C,ZNF426,SOS1 |
| zinc ion binding | ZDHHC14,MAN2A1,LANCL1,CXXC4,PRDM4,FTR50,KDM2A,NSMCE1,NEIL2,CA15B |
| poly(A) RNA binding | XRCC6,TDRD9,HSP90AA1,HSPA8,RCC2,METTL16,GRWD1,TCOF1,TBRG4,G3BP1 |
| nucleotide binding | NIM1,ACVR1L,DHRS3,HNRNPA0A,TNIKA,RBM4.2,ATP2B1,CDC34B,CKBA,GDPGP1 |
| DNA binding | MSH2,BRCA1,HDGFRP2,RPAP1,THAP2,ZNF41,ZNF37A,HOXA11B,TAF1A,FOXL2 |
Interacting Protein
TAF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF15.
FUS;fus_ddit3;PLEC;Taf15;CACNA1A;avtA2;sSL2;menB;q81xx8_bacan;q8d1p4_yerpe;pre-let-7a
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