TADA2B
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Official Full Name
transcriptional adaptor 2B -
Overview
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone;acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al.,;2003 (PubMed 12972612)). -
Synonyms
TADA2B;transcriptional adaptor 2B;transcriptional adapter 2-beta;MGC21874;ADA2 beta;ADA2 like protein beta;ADA2B;MGC21874 protein;TAD 2B;TAD2 beta;TAD2B;Transcriptional adapter 2 beta;transcriptional adaptor 2;yeast ADA2 homolog beta;ADA2-beta;OTTHUMP00000217249;OTTHUMP00000217250;ADA2-like protein beta;transcriptional adaptor 2 (ADA2 homolog, yeast)-beta;ADA2(beta)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TADA2B-3097H | Recombinant Human TADA2B, His-tagged | E.coli | Human | His | C-term-206aa | |
| TADA2B-3041Z | Recombinant Zebrafish TADA2B | Mammalian Cells | Zebrafish | His |
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| TADA2B-4343H | Recombinant Human TADA2B Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
TADA2B involved in several pathways and played different roles in them. We selected most pathways TADA2B participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TADA2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | MBD3B,PBRM1,PRMT7,C20orf20,KAT7,ATXN7,KAT7B,KDM5A,SMARCB1B,MBD3 |
| Direct p53 effectors | PRDM1,SMARCA4,DUSP1,RNF144B,CTSD,BCL2L14,HIC1,FDXR,EPHA2,PLK3 |
| HATs acetylate histones | KAT7B,TADA2A,C20orf20,KANSL2,KAT7A,PHF17,C3orf75,MORF4L2,ELP4,JADE1 |
| Chromatin organization | KDM5BB,KAT7B,KAT7A,COPRS,PBRM1,MEAF6,KANSL3,PADI1,KDM5BA,MSL1 |
Protein Function
TADA2B has several biochemical functions, for example, DNA binding,chromatin binding,contributes_to histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TADA2B itself. We selected most functions TADA2B had, and list some proteins which have the same functions with TADA2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | BIRC8,ZDHHC5,SMAD3,ADAM21,WTIP,NR2F2,ZDHHC16A,KDM1B,PGR,TRAF7 |
| transcription coactivator activity | NFKBIB,RAN,SAP130,WWC1,CTBP2,TDRD3,SERTAD2,GTF2A2,VGLL1,ZEB1 |
| contributes_to histone acetyltransferase activity | TAF6L,KAT2A,TAF5L,TAF9,TADA1,TADA3,ELP4,TAF10,EPC1,TAF12 |
| DNA binding | NKX2.5,NKX1.2LB,MLF1,PAX6A,SIM1,MSXE,HIST1H2BB,ZFP488,FOXO1B,NCOR2 |
| transcription factor activity, sequence-specific DNA binding | SIM1A,E2F5,ZNF498,ZFP28,NEUROD2,PROX1,HSF5,POU2F1B,FOXC1A,MSC |
| chromatin binding | CAMTA2,SOX14,HMGB1A,CHAF1B,STAT5B,ARNTL1B,EYA3,CHD8,KAT2A,CRX |
Interacting Protein
TADA2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TADA2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TADA2B.
USP22;CCDC101;TRRAP
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References
- Goulet, ML; Olagnier, D; et al. Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. PLOS PATHOGENS 9:-(2013).
- Kornet, N; Scheres, B; et al. Members of the GCN5 Histone Acetyltransferase Complex Regulate PLETHORA-Mediated Root Stem Cell Niche Maintenance and Transit Amplifying Cell Proliferation in Arabidopsis. PLANT CELL 21:1070-1079(2009).
