TAC1
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Official Full Name
tachykinin, precursor 1 -
Overview
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
TAC1;tachykinin, precursor 1;NK2;NPK;NKNA;TAC2;Hs.2563;protachykinin-1;PPT;substance K;substance P;neurokinin 1;neurokinin 2;neurokinin A;neuromedin L;tachykinin 2;neuropeptide K;neurokinin alpha;preprotachykinin;neuropeptide gamma;tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Cynomolgus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- Protein Conjugation
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
TAC1 involved in several pathways and played different roles in them. We selected most pathways TAC1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | RGS20,CDC42EP1B,RGR,OPHN1,LRIG1,PLEKHG2,RHOU,TAC2,KREMEN1,CCRL2 |
| G alpha (q) signalling events | OPN4A,NMB,PROKR2,CHRM1,GPR68,PRKCHB,CASR,TRPC6A,LPAR5A,NPFF |
| Peptide ligand-binding receptors | RLN3A,INSL3,CCL35.1,PYY,NPFF,NTS,PYYA,PROK1,NPSR1,NMS |
| Class A/1 (Rhodopsin-like receptors) | PNOC,EDNRAB,OXGR1A.2,ADRA1B,KISS1,NMUR1,EDNRA,NPS,GPR132B,RLN3 |
| SIDS Susceptibility Pathways | MECP2,MAZ,TSPYL1,SCN3B,PHOX2A,EN1,POU2F2,GATA2,PLP1,SP3 |
| GPCR ligand binding | OXGR1A.1,EMR4,GCGB,NMUR1,CHRM5,NMBB,S1PR1,PROKR1A,OXGR1A.3,RGR |
| Gastrin-CREB signalling pathway via PKC and MAPK | RGS19,UTS2,NPS,KISS1,ABHD6B,TAC3,PROKR1A,GCGB,FFAR3,RASGRP2 |
| GPCR downstream signaling | FPR-RS3,DRD3,TAC2,RGR,NPSR1,TRPC7,OR52B4,LTB4R,AGT,GCGB |
Protein Function
TAC1 has several biochemical functions, for example, protein binding,receptor binding,substance P receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAC1 itself. We selected most functions TAC1 had, and list some proteins which have the same functions with TAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PVRL2,CDH5,HLA-G,SLC9A3R1,Itga10&Itgb1,CADM2A,GLA,KCNJ10,FGF1A,CCL17 |
| protein binding | ARHGEF3,TUBGCP4,GADD45A,RFX1,MAP3K7,EHHADH,TTC12,FRS2,FAM64A,CLCN1 |
Interacting Protein
TAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAC1.
DPP4;FAP;CENPB;XRCC6;BAG6;CRELD2;ARHGEF40
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