SURF1
-
Official Full Name
surfeit 1 -
Overview
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. -
Synonyms
SURF1;surfeit 1;surfeit locus protein 1;MS403;OTTHUMP00000022473;OTTHUMP00000022474;SURF 1;SURF-1;SURF1_HUMAN
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Drosophila melanogaster (Fruit fly)
- Arabidopsis thaliana
- Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
SURF1 involved in several pathways and played different roles in them. We selected most pathways SURF1 participated on our site, such as Electron Transport Chain,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SURF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | NDUFAF4,C20orf7,FAM36A,NDUFAF2,UCP2,ETFA,ATP5L,COX14,SLC25A27,UCP3 |
| Electron Transport Chain | COX6A2,COX6A1,COX7C,COX11,ATP5S,NDUFS7,COX5B,COX17,SLC25A14,SLC25A27 |
| The citric acid (TCA) cycle and respiratory electron transport | PDP2,PDP1,COX16,NDUFAF5,SLC25A27,NDUFAF7,COX18,NDUFAF4,NDUFAF6,SCO1 |
| Metabolism | ALOX5AP,ELA2,COX10,KCNG4,NAGS,DBH,CYP4T8,SLC25A2,MED8,CES1 |
| Gene Expression | CDKAL1,GLS2B,FAM36A,ZNF285A,ZNF567,QTRTD1,CRCP,TSEN15,THOC4,ADARB1 |
| Generic Transcription Pathway | NR2C2AP,NR1D2,ZNF446,YAP1,ZNF19,MED8,ZNF484,CDK9,ZNF157,ZNF547 |
| Respiratory electron transport | C2orf56,C20orf7,NDUFAF5,NDUFAF7,ETFA,NDUFAF2,COX14,TIMMDC1,ETFDH,NDUFAF3 |
| TP53 Regulates Metabolic Genes | PRDX2,COX18,FAM36A,COX16,COX14,TACO1,SCO1,LRPPRC,SESN3 |
Protein Function
SURF1 has several biochemical functions, for example, cytochrome-c oxidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SURF1 itself. We selected most functions SURF1 had, and list some proteins which have the same functions with SURF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | CYB5A,COX5A,COX6B2,COX6A2,COX11,COX6A1,COX8A,COX7A1,COX5B2,COX7A2A |
| protein binding | CIB2,SCRN2,STIP1,OTUB2,NDUFA4,MARK2,ARNTL2,ZNF614,CDON,TIPIN |
Interacting Protein
SURF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SURF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SURF1.
COA3;PTGES3;SLC25A5;COX6C;COX14;COA1
Resources
Related Services
Related Products
References
