STK11
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Official Full Name
serine/threonine kinase 11 -
Overview
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] -
Synonyms
STK11;serine/threonine kinase 11;PJS;LKB1;hLKB1;serine/threonine-protein kinase STK11;liver kinase B1;polarization-related protein LKB1;renal carcinoma antigen NY-REN-19;serine/threonine-protein kinase 11;serine/threonine-protein kinase LKB1
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- Sf21 Cells
- His
- GST&His
- Non
- His&Myc
- GST
- Avi&Fc&His
- His&SUMO
Involved Pathway
STK11 involved in several pathways and played different roles in them. We selected most pathways STK11 participated on our site, such as FoxO signaling pathway,mTOR signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | PTPN11B,ACSL4B,TNF,PRKAG2,G6PC3,CHUK,RXRB,LEP,IKBKG,PRKAG3 |
| FoxO signaling pathway | IRS4,GADD45BA,MAPK8A,INS2,PIK3R3,IGF1,FOXO4,CCNB2,FOXO1,FOXO1B |
| mTOR signaling pathway | TSC2,CAB39L,AKT2,PTENB,POLDIP3,RPTOR,RPS6KAL,EIF4E1C,RPS6KA6,RRN3 |
| PIK-Akt signaling pathway | TCL1B,PIK3CA,TP53,IFNA10,MAPK1,GNG10,NR4A1,YWHAH,VTN,GSK3B |
| AMPK signaling pathway | CREB1,CPT1B,PPP2R2C,CREB3L1,CREB5,PFKFB4,CREB3L3,PRKAG2,LEPR,EEF2K |
Protein Function
STK11 has several biochemical functions, for example, ATP binding,LRR domain binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK11 itself. We selected most functions STK11 had, and list some proteins which have the same functions with STK11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WRAP53,ZNF274,MAD2L1BP,AGPS,SGCA,NEUROD1,ZFP932,EPN3,ZUFSP,FOXC2 |
| p53 binding | TRP53,NTRK3,AXIN1,KDM1A,MSX1,SETD7,ZFP385C,USP10,NUAK1,ZMAT4 |
| protein serine/threonine kinase activity | TRPM6,TLK2,BMPR1AB,MELK,MAP3K14,MAPK14B,LMTK3,NEK3,STK19,RPS6KA5 |
| ATP binding | RPS6KA5,NSFA,MYO10,SPHK1,SMC3,ABCB6,AKT3A,EIF4A1B,PPP2R4,TRPV1 |
| magnesium ion binding | ALPP,PINK1,INPP1,NT5C1A,DUT,ENOPH1,PI4K2A,COMT,ZNF143B,ADSSL1 |
| protein kinase activator activity | TOM1L1,DBF4B,NKX3-1,MARK2,DUSP19,GPRC5B,MT3,FAM58A,DAXX,FGF13 |
| protein complex binding | THRA,SLC27A5,PDZK1,HCLS1,CCND1,TUB,RAN,KRT8,GNB4,FBN1 |
| LRR domain binding | ROBO1,LRRFIP2,KRAS,POLR2J,ZXDC |
Interacting Protein
STK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK11.
STRADA;CAB39
STK11 Related Signal Pathway
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References
- Nakada, Y; Stewart, TG; et al. The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues. PLOS ONE 8:-(2013).
- Zhong, DS; Liu, XJ; et al. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. CANCER RESEARCH 68:7270-7277(2008).
