ST8SIA2
-
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -
Overview
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. -
Synonyms
ST8SIA2;ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2;sialyltransferase 8 (alpha 2, 8 sialytransferase) B , SIAT8B;alpha-2,8-sialyltransferase 8B;HsT19690;ST8SIA II;STX;SIAT8-B;ST8SiaII;sialyltransferase X;sialyltransferase 8B;si
Recombinant Proteins
- Chicken
- Mouse
- Pan troglodytes
- Rat
- Zebrafish
- Human
- Mus musculus
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- E.coli
- His
- Non
- His&GFP
- His&Fc&Avi
Involved Pathway
ST8SIA2 involved in several pathways and played different roles in them. We selected most pathways ST8SIA2 participated on our site, such as Asparagine N-linked glycosylation,Axon guidance,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST8SIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | PEA15,EPHB4,PPP3CC,HRAS,LOC608458,Sema3f,RASGRP1,UNC5D,RGMA,L1CAM |
| Metabolism of proteins | GALNTL5,CXXC1,TIMM50,CBX4,IGFBP2A,INHBAA,CNIH3,IGFBP5B,TRAPPC2L,TIMM22 |
| Developmental Biology | EPHA2A,IL17RD,MED22,ACTR3,DCX,LIN28A,EFNB3,HELZ2,MED10,SPTA1 |
| N-Glycan antennae elongation | MGAT4B,MGAT4A,ST8SIA3 |
| NCAM signaling for neurite out-growth | COL9A1B,PSPN,GFRA1,NRTN,COL9A1A,GFRA2,GFRA4,GDNF |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ST6GAL2B,ST6GALNAC1.2,NANP,ZNF408,MPDU1A,NEU3,ST6GALNAC2,ALG14,MPDU1,MPDU1B |
| Asparagine N-linked glycosylation | PREB,NEU4,CTSC,AREG,TRAPPC1,MCFD2,SLC35A1,NANP,SERPINA1L,MGAT4A |
| N-glycan antennae elongation in the medial/trans-Golgi | MGAT4A,MGAT4B,ST8SIA3 |
Protein Function
ST8SIA2 has several biochemical functions, for example, alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity,sialic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ST8SIA2 itself. We selected most functions ST8SIA2 had, and list some proteins which have the same functions with ST8SIA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | ST8SIA3,ST8SIA5,ST8SIA1 |
| sialic acid binding | Siglece,FCN1,AGRN,SELP,L1CAM,ST8SIA3,ADIPOQ,SELE |
Interacting Protein
ST8SIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST8SIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST8SIA2.
Resources
Related Services
Related Products
References
- Matarrese, P; Garofalo, T; et al. Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation. AUTOPHAGY 10:750-765(2014).
- Hamada, Y; Saigoh, K; et al. Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus. NEUROSCIENCE LETTERS 535:12-17(2013).
- Lee, MTM; Chen, CH; et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. MOLECULAR PSYCHIATRY 16:548-556(2011).
- Husain, S; Yildirim-Toruner, C; et al. Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis. PLOS ONE 3:-(2008).
