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ST6GALNAC2

Official Full Name

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Overview

ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates.;At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion,;and protein targeting (Samyn-Petit et al., 2000 (PubMed 10742600)).
Synonyms

ST6GALNAC2; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; sialyltransferase 7 ((alpha N acetylneuraminyl 2,3 beta galactosyl 1,3) N acetyl galactosaminide alpha 2,6 sialyltransferase) , sialyltransferase like 1 , SIAT7, SIAT7B, SIATL1; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAII; STHM; SAITL1; (alpha N acetylneuraminyl 2 3 beta galactosyl 1 3) N acetyl galactosaminide alpha 2 6 sialyltransferase; (alpha N acetylneuraminyl 2 3 beta galactosyl 1 3) N acetyl galactosaminide B; Alpha N acetylgalactosaminide alpha 2 6 sialyltransferase 2; FLJ45660; GalNAc alpha 2 6 sialyltransferase II; Sialyltransferase 7; Sialyltransferase 7B; Sialyltransferase like 1; Sialyltransferase7; SIAT7; SIAT7B; SIATL1; ST6 (alpha N acetyl neuraminyl 2 3 beta galactosyl 1 3) N acetylgalactosaminide alpha 2 6 sialyltransferase 2; ST6GalNAc II; SIAT7-B; ST6GalNAcII; sialyltransferase-like 1; galNAc alpha-2,6-sialyltransferase II; (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B; (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
E.Coli or Yeast
HEK293
Human Cell
Mammalian Cell
Mammalian cells

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ST6GALNAC2-2979H	Recombinant Human ST6GALNAC2, His-tagged	E.coli	His	38-374aa	$319 / 25μg
Human	ST6GALNAC2-195H	Recombinant Human ST6GALNAC2, His-tagged	HEK293	His	Met1-Arg374	Inquiry
Human	ST6GALNAC2-16H	Active Recombinant Human ST6GALNAC2 Protein (AA 68-374), N-6×His/GFP tagged	HEK293	His&GFP	AA 68-374	Inquiry
Human	ST6GALNAC2-5563H	Recombinant Human ST6GALNAC2 Protein (Ser29-Arg374), C-His tagged	Mammalian cells	His	Ser29-Arg374	Inquiry
Mouse	ST6GALNAC2-912M	Recombinant Mouse ST6GALNAC2 Protein, His-tagged	HEK293	His	Ser28-Arg373	Inquiry
Mouse	St6galnac2-3379M	Recombinant Mouse St6galnac2, His-tagged	E.Coli or Yeast	His	373	Inquiry
Mouse	ST6GALNAC2-1613MCL	Recombinant Mouse ST6GALNAC2 cell lysate	Human Cell	Non		Inquiry
Mus musculus (Mouse)	RFL6619MF	Recombinant Full Length Mouse Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2(St6Galnac2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-373)	Inquiry
Zebrafish	ST6GALNAC2-7662Z	Recombinant Zebrafish ST6GALNAC2	Mammalian Cell	His		Inquiry
Chicken	ST6GALNAC2-6786C	Recombinant Chicken ST6GALNAC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ST6GALNAC2 involved in several pathways and played different roles in them. We selected most pathways ST6GALNAC2 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST6GALNAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asparagine N-linked glycosylation	MPDU1;USO1;ALG14;GNE;TRAPPC10;SEC16B;NANP;TRAPPC2;TRAPPC1
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	ST6GALNAC1.2;ST8SIA3;NEU4;ST3GAL3A;MPDU1;ST6GALNAC2;ZNF408;GNE;SLC35A1
Metabolism of proteins	YIF1A;CNIH2;BCS1L;SEC22A;TBCB;SLC30A8;TRAPPC3;PPP6R3;COX17
O-linked glycosylation	A4GNT;ADAMTS13;C8orf84;B3GNT2A;ADAMTSL3;MUC20;GCNT3;ST6GALNAC2;ADAMTSL4
O-linked glycosylation of mucins	KCNA6;MUC21;GALNT5;MUCL1;GALNT6;B3GNT6;B3GNT8;MUC20;GALNTL5
Post-translational protein modification	ARSF;TRAPPC5;MAN1A2;ADAMTS5;MUCL1;TMED2;THSD7A;SEC22A;ANKRD28
Sialic acid metabolism	ST6GALNAC1.2;ST8SIA3;ST6GALNAC2;GNE;ST6GAL2B;SLC35A1;NANP
Synthesis of substrates in N-glycan biosythesis	ST6GALNAC1.2;ST6GALNAC2;ST6GAL2B;ST8SIA3;GNE;SLC35A1

ST6GALNAC2 has several biochemical functions, for example, sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST6GALNAC2 itself. We selected most functions ST6GALNAC2 had, and list some proteins which have the same functions with ST6GALNAC2. You can find most of the proteins on our site.

Function	Related Protein
sialyltransferase activity	ST6GAL1;ST6GALNAC3;ST8SIA1;ST3GAL3B;ST6GALNAC2;ST3GAL2L;ST6GAL2A;ST6GALNAC5B;ST6GAL2B

ST6GALNAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST6GALNAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST6GALNAC2.

SMAD3

Research Area

Kroes, RA; He, HA; et al. Overexpression of ST6GalNAcV, a ganglioside-specific alpha 2,6-sialyltransferase, inhibits glioma growth in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:12646-12651(2010).