ST6GALNAC1
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Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 -
Overview
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of;intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage;to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed;sialylation of GalNAc residues on mucins (Ikehara et al., 1999 (PubMed 10536037); Sewell et al., 2006 (PubMed;16319059)). -
Synonyms
ST6GALNAC1;ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1;sialyltransferase 7 ((alpha N acetylneuraminyl 2,3 beta galactosyl 1,3) N acetyl galactosaminide alpha 2,6 sialyltransferase) A , SIAT7A;alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1;ST6GalNAcI;6-sialyltransferase 1;6-sialyltransferase I;Alpha N acetylgalactosaminide alpha 2 6 sialyltransferase 1;Alpha N acetylgalactosaminide alpha 2 6 sialyltransferase;Alpha-N-acetylgalactosaminide alpha-2;GalNAc alpha 2 6 sialyltransferase I;GalNAc alpha-2;HSY11339;SIA7A_HUMAN;Sialyltransferase 7A;SIAT7-A;SIAT7A;ST6 (alpha N acetyl neuraminyl 2 3 beta galactosyl 1 3) N acetylgalactosaminide alpha 2 6 sialyltransferase 1;ST6GalNAc I;STYI;galNAc alpha-2,6-sialyltransferase I;GalNAc alpha-2, 6-sialyltransferase I, long form;sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A
Recombinant Proteins
- Mouse
- Chicken
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&GFP
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ST6GALNAC1-16070M | Recombinant Mouse ST6GALNAC1 Protein | Mammalian Cell | Mouse | His |
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| ST6GALNAC1-6793C | Recombinant Chicken ST6GALNAC1 | Mammalian Cell | Chicken | His |
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| ST6GALNAC1-1438HCL | Recombinant Human ST6GALNAC1 293 Cell Lysate | HEK293 | Human | Non |
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| ST6GALNAC1-15H | Active Recombinant Human ST6GALNAC1 Protein (AA 36-600), N-6×His/GFP tagged | HEK293 | Human | His&GFP | AA 36-600 |
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| ST6GALNAC1-17H | Active Recombinant Human ST6GALNAC1 Protein (AA 36-600), N-6×His/GFP tagged | HEK293 | Human | His&GFP | AA 36-600 |
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| ST6GALNAC1-8763M | Recombinant Mouse ST6GALNAC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ST6GALNAC1-8763M-B | Recombinant Mouse ST6GALNAC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ST6GALNAC1 involved in several pathways and played different roles in them. We selected most pathways ST6GALNAC1 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST6GALNAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PPAP2C,UGT1A7C,POLR2L,MGAT2,GCLM,B3GALT2,SPAM1,LDHAL6A,CYP21A1,TYMP |
| Mucin type O-Glycan biosynthesis | GALNT12,POC1B-GALNT4,GCNT1,GALNT5,C1GALT1C1,GALNTL6,B3GNT6,GALNTL1,GALNT9,GALNT1 |
Protein Function
ST6GALNAC1 has several biochemical functions, for example, alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity,sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST6GALNAC1 itself. We selected most functions ST6GALNAC1 had, and list some proteins which have the same functions with ST6GALNAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sialyltransferase activity | ST8SIA5,ST6GALNAC5,ST3GAL2L,ST3GAL5L,ST6GAL2B,ST6GAL2A,ST6GALNAC6,ST6GALNAC3,ST6GALNAC4,ST3GAL3A |
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | ST6GALNAC5B,ST6GALNAC4,ST6GALNAC6,ST6GALNAC1.2,ST6GALNAC5,ST6GALNAC3 |
Interacting Protein
ST6GALNAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST6GALNAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST6GALNAC1.
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References
- Kato, T; Iwamoto, K; et al. Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders. NEUROPHARMACOLOGY 80:133-139(2014).
