SRGAP3
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Official Full Name
SLIT-ROBO Rho GTPase activating protein 3 -
Overview
srGAP3 (SLIT ROBO Rho GTPase-activating protein 3) is a GTPase activating protein (GAP) for the small G protein Rac. It has a putative role in attenuating Rac1 signalling in neurons. srGAP3 is thought to act downstream of the Slit-Robo pathway, which regulates neuronal migration and axonal branching, and play an important role in axonal regeneration after axotomy. It also plays a putative role in severe mental retardation. -
Synonyms
SRGAP3;SLIT-ROBO Rho GTPase activating protein 3;WRP;MEGAP;SRGAP2;ARHGAP14;SLIT-ROBO Rho GTPase-activating protein 3;mental disorder-associated GAP;rho GTPase-activating protein 14;SLIT-ROBO Rho GTPase activating protein 2;WAVE-associated Rac GTPase activating protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SRGAP3-2951H | Recombinant Human SRGAP3, GST-tagged | E.coli | Human | GST | 121-442aa | |
| SRGAP3-2316C | Recombinant Chicken SRGAP3 | Mammalian Cell | Chicken | His |
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| SRGAP3-631HCL | Recombinant Human SRGAP3 lysate | HEK293 | Human | Non |
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| SRGAP3-2745H | Recombinant Human SRGAP3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Srgap3-6126M | Recombinant Mouse Srgap3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SRGAP3-970H | Recombinant Human SRGAP3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
SRGAP3 involved in several pathways and played different roles in them. We selected most pathways SRGAP3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRGAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | DPYSL3,AKAP9,AP2S1,SEMA6A,RASGEF1A,DCX,NCAN,SCN4A,PPP3R1,KBTBD7 |
Protein Function
SRGAP3 has several biochemical functions, for example, GTPase activator activity,Rac GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRGAP3 itself. We selected most functions SRGAP3 had, and list some proteins which have the same functions with SRGAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | NOX1,FLNA,PKN1,DVL1,SRGAP2,PAK4,ARHGAP4A,PAK2,MAP3K11,ARFIP2 |
| protein binding | EFTUD2,TLDC2,CYBB,SH2D1B,ENTPD1,RRAGD,FGF2,ZNF398,EEF1D,OSGIN1 |
| GTPase activator activity | TBC1D15,JUN,ERRFI1,ASAP3,SMAP2,ADAP2,DEPDC1,OCRL,ARHGAP33,ARAP3 |
Interacting Protein
SRGAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRGAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRGAP3.
Amph;Sh3gl2;Sh3gl1;GRB2;cc3;Dlg4;FASLG;Grb2;SH3GL1;SH3GL2;SUV39H1;KDM1A
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References
- Zhang, QP; Zhang, HY; et al. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1. ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 7:630-638(2014).
