SPTLC2
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Official Full Name
serine palmitoyltransferase, long chain base subunit 2 -
Overview
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. -
Synonyms
SPTLC2;serine palmitoyltransferase, long chain base subunit 2;serine palmitoyltransferase 2;hLCB2a;KIAA0526;LCB2;LCB2A;LCB 2;Long chain base biosynthesis protein 2;Long chain base biosynthesis protein 2a;Serine palmitoyl CoA transferase 2;Serine palmitoyltransferase long chain base subunit 2;Serine palmitoyltransferase subunit II;Serine-palmitoyl-CoA transferase 2;SPT 2;SPT2;SPTC2_HUMAN;SPTLC 2;OTTHUMP00000246380;OTTHUMP00000246382;serine palmitoyltransferase, subunit II;HSN1C;NSAN1C
Recombinant Proteins
- Mouse
- Chicken
- Human
- Cricetulus griseus
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- SUMO
- Avi
- Fc
Involved Pathway
SPTLC2 involved in several pathways and played different roles in them. We selected most pathways SPTLC2 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTLC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | NFKB1,KRAS,TRADD,LASS5,MAPK8,MAPK1,MAPK12,SPTLC3,SPTLC1,PIK3R2 |
| Metabolic pathways | NT5C2,ATP5L,NAMPTB,DOLK,FAH,TYRP1B,Atp5k,SPRA,ATP6V0D2,POLR2J2 |
| Sphingolipid metabolism | CERS1,ASAH1A,SGPP1,SGPP2,GAL3ST1A,GLTPA,GBA,CERK,B4GALT6,SPHK1 |
Protein Function
SPTLC2 has several biochemical functions, for example, pyridoxal phosphate binding,serine C-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTLC2 itself. We selected most functions SPTLC2 had, and list some proteins which have the same functions with SPTLC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine C-palmitoyltransferase activity | SPTLC1,SPTLC3 |
| pyridoxal phosphate binding | GOT2A,HDC,AGXT2L1,MOSC2,SPTLC3,CTH,GPT2,DDC,LOC650128,PYGMA |
Interacting Protein
SPTLC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTLC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTLC2.
q7chd9_yerpe;ATG2A;d-mannose;1C;BCL6
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