SPG7
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Official Full Name
spastic paraplegia 7 (pure and complicated autosomal recessive) -
Overview
This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7. -
Synonyms
SPG7;spastic paraplegia 7 (pure and complicated autosomal recessive);cell matrix adhesion regulator , CMAR;paraplegin;CAR;SPG5C;Cell adhesion regulator;Cell matrix adhesion regulator;CMAR;PGN;Spastic paraplegia 7 homolog (human);Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive);Spastic paraplegia protein 7;SPG7 gene;paraplegin, isoform 1;spastic paraplegia 7 protein
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
SPG7 involved in several pathways and played different roles in them. We selected most pathways SPG7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPG7 has several biochemical functions, for example, ATP binding,ATP-dependent peptidase activity,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG7 itself. We selected most functions SPG7 had, and list some proteins which have the same functions with SPG7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | HSP104,HSP90AA1.1,PPIB,HSPA1B,CCT7,DNAJA2,HSPE1,H2-KE2,CCT8,TOR1A |
| zinc ion binding | ZNF385A,QTRTD1,TRIM35-30,ZGLP1,DPF2L,RFPL4,LHX1,PDXK,EWSR1B,LPP |
| ATP-dependent peptidase activity | AFG3L2,LONP1,YME1L1,LONRF1L,LONRF2,CRBN,LONRF3 |
| ATP binding | ACTG1,AK1,DNAJA4,MTPAP,P2RY1,ABCA4A,DGKG,ERCC3,NMRK1,ADK |
| peptidase activity | TMPRSS7,Ctsl,KLK1B24,BMP1,REN,TMPRSS4A,PSD,HTRA1A,Ren1,NPEPPS |
| metalloendopeptidase activity | ADAM8A,MMP1A,PITRM1,MMP9,BMP1B,ADAMTS2,UQCRC1,MMP26,MMP30,ADAM33 |
| protein binding | KRTAP12-4,SRSF10,FAM134B,C19orf57,SPIN1,KIF9,VEGFAA,cgr2b,SMC4,FIBCD1 |
Interacting Protein
SPG7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG7.
MTUS2;PNMA1;MDFI;PSTPIP1;CCNDBP1
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References
- Blumkin, L; Lerman-Sagie, T; et al. A new locus (SPG47) maps to 1p13.2-1p12 in an Arabic family with complicated autosomal recessive hereditary spastic paraplegia and thin corpus callosum. JOURNAL OF THE NEUROLOGICAL SCIENCES 305:67-70(2011).
- Deeken, JF; Cormier, T; et al. A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform. PHARMACOGENOMICS JOURNAL 10:191-199(2010).
