SPAST
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Official Full Name
spastin -
Overview
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. -
Synonyms
SPAST;spastin;spastic paraplegia 4 (autosomal dominant;spastin) , SPG4;ADPSP;FSP2;KIAA1083;FSP 2;Spastic paraplegia 4;SPG 4;SPG4;spastic paraplegia 4 protein;spastin)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Mus musculus
- Xenopus laevis
- Bovine
- zebrafish
- Sus scrofa (Pig)
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
SPAST involved in several pathways and played different roles in them. We selected most pathways SPAST participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPAST has several biochemical functions, for example, ATP binding,alpha-tubulin binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAST itself. We selected most functions SPAST had, and list some proteins which have the same functions with SPAST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | VARS2,ATP5B,GK5,IP6K3,DDR1,CDK7,DDX10,ATP13A5,NEK2,SMC6 |
| protein binding | VIPAS39,BANF1,PDCD10,ACTL8,PSMA7,IFI16,ZP3,TRAF1,MYH11,PELI1 |
| alpha-tubulin binding | OFD1,HDAC6,PPARGC1A,ARL4C,PACRG,NCALD,INO80,SLC6A2,C9orf24,RACGAP1 |
| microtubule binding | DPYSL2,KATNA1,KIF11,KIF23,CAMSAP1,KIF27,KIF3B,GCAP14,MTAP4,NUMA1 |
| beta-tubulin binding | PDCD5,MAP1S,RANBP10,HTT,ARL8B,PIFO,VAPB,SERPINB1A,RACGAP1,SNCA |
| microtubule-severing ATPase activity | ATAD1B,ATAD1,KATNAL2,KATNAL1,FIGN,FIGNL1,ATAD1A |
Interacting Protein
SPAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAST here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAST.
q8cl55_yerpe;ALB;GAS2L3;AURKB
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