SPAST
-
Official Full Name
spastin -
Overview
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. -
Synonyms
SPAST;spastin;spastic paraplegia 4 (autosomal dominant;spastin) , SPG4;ADPSP;FSP2;KIAA1083;FSP 2;Spastic paraplegia 4;SPG 4;SPG4;spastic paraplegia 4 protein;spastin)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Mus musculus
- Xenopus laevis
- Bovine
- zebrafish
- Sus scrofa (Pig)
- E.coli
- Mammalian Cell
- E.coli expression system
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- His&Fc&Avi
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPAST-2901H | Recombinant Human SPAST, GST-tagged | E.coli | Human | GST | 79-278aa | |
| SPAST-2537H | Recombinant Human SPAST protein, His-tagged | E.coli | Human | His | 79-278 aa | |
| SPAST-12168Z | Recombinant Zebrafish SPAST | Mammalian Cell | Zebrafish | His |
|
|
| SPAST-15819M | Recombinant Mouse SPAST Protein | Mammalian Cell | Mouse | His |
|
|
| SPAST-2741C | Recombinant Chicken SPAST | Mammalian Cell | Chicken | His |
|
|
| SPAST-5685R | Recombinant Rat SPAST Protein | Mammalian Cell | Rat | His |
|
|
| RFL10255MF | Recombinant Full Length Mouse Spastin(Spast) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-614) |
|
| RFL16855XF | Recombinant Full Length Xenopus Laevis Spastin(Spast) Protein, His-Tagged | E.coli expression system | Xenopus laevis | His | Full L. Full Length (1-600) |
|
| RFL176BF | Recombinant Full Length Bovine Spastin(Spast) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-614) |
|
| RFL18501DF | Recombinant Full Length Danio Rerio Spastin(Spast) Protein, His-Tagged | E.coli expression system | zebrafish | His | Full L. Full Length (1-570) |
|
| RFL19823RF | Recombinant Full Length Rat Spastin(Spast) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-581) |
|
| RFL36314SF | Recombinant Full Length Pig Spastin(Spast) Protein, His-Tagged | E.coli expression system | Sus scrofa (Pig) | His | Full L. Full Length (1-613) |
|
| RFL931GF | Recombinant Full Length Chicken Spastin(Spast) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length (1-613) |
|
| SPAST-2082H | Recombinant Human SPAST Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| SPAST-2082H-B | Recombinant Human SPAST Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| SPAST-2416H | Recombinant Human SPAST Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| SPAST-369HFL | Recombinant Full Length Human SPAST Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| SPAST-5187H | Recombinant Human SPAST Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| SPAST-5344R | Recombinant Rat SPAST Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| SPAST-5344R-B | Recombinant Rat SPAST Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Spast-6075M | Recombinant Mouse Spast Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| SPAST-8609M | Recombinant Mouse SPAST Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| SPAST-8609M-B | Recombinant Mouse SPAST Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SPAST involved in several pathways and played different roles in them. We selected most pathways SPAST participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPAST has several biochemical functions, for example, ATP binding,alpha-tubulin binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAST itself. We selected most functions SPAST had, and list some proteins which have the same functions with SPAST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACSBG1,SGK2,WEE2,Ckmm,CSNK1G2A,ROS1,ADCY7,NUBP2,QRSL1,PET112L |
| alpha-tubulin binding | PPARGC1A,SERPINB1A,ARL8A,FAM110C,INO80,SLC6A2,WASH1,ARL4C,PACRG,HDAC6 |
| microtubule-severing ATPase activity | FIGNL1,ATAD1A,ATAD1,ATAD1B,FIGN,KATNAL2,KATNAL1 |
| microtubule binding | KIF23,MAP1LC3B,GAPDH,NUSAP1,CETN2,NEIL2,CLASP1,FNTA,RGS14,MID2 |
| beta-tubulin binding | SLC6A2,PEX14,RGS2,EMD,TRPV4,HTT,RANBP10,MAP1S,B4GALT1,BBS4 |
| protein binding | RFX3,CCNA1,KIAA1279,RECQL4,KRT4,TIRAP,EME1,EBF2,SEC14L4,CC10 |
Interacting Protein
SPAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAST here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAST.
q8cl55_yerpe;ALB;GAS2L3;AURKB
Resources
Related Services
Related Products
References
