SOX7

  • Official Full Name

    SRY (sex determining region Y)-box 7

  • Overview

    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

  • Synonyms

    SOX7;SRY (sex determining region Y)-box 7;transcription factor SOX-7

Recombinant Proteins

  • Mouse
  • Human
  • Zebrafish
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SOX7-15786M Recombinant Mouse SOX7 Protein Mammalian Cell Mouse His
SOX7-173H Recombinant Human SOX7 protein, T7/His-tagged E.coli Human His&T7
SOX7-294H Recombinant Human SOX7 Protein, His-tagged E.coli Human His
SOX7-5171Z Recombinant Zebrafish SOX7 Mammalian Cell Zebrafish His
SOX7-1556HCL Recombinant Human SOX7 293 Cell Lysate HEK293 Human Non
SOX7-2722H Recombinant Human SOX7 Protein, His-tagged E.coli Human His Gln217-Ser388
SOX7-8593M Recombinant Mouse SOX7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SOX7-8593M-B Recombinant Mouse SOX7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SOX7 involved in several pathways and played different roles in them. We selected most pathways SOX7 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TCF dependent signaling in response to WNT RNF43,USP34,SOX13,RBBP5,DACT1,BCL9L,TNKS2,RSPO2,KLHL12,TNKS
    Signal Transduction AKR1C6,APOA4A,RGS4,ARHGAP24,NEDD8L,ARHGEF3,ARHGEF17,LPAR2A,GRAP,CSHL1
    Deactivation of the beta-catenin transactivating complex TLE1,BCL9L,CTBP1,SOX9B,ASH2L,SOX4A,SOX13,TLE2,CBY1,TLE3B
    Signaling by Wnt HECW1,RSPO2,FAM123B,TNKS,LGR6,ROR2,ZNRF3,SOX9B,RYK,PRICKLE1

    Protein Function

    SOX7 has several biochemical functions, for example, protein binding,sequence-specific DNA binding,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX7 itself. We selected most functions SOX7 had, and list some proteins which have the same functions with SOX7. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding CEBPA,MEF2A,SOX17,FOXF2A,CEBPB,T,SOX9,RFX1,FOXC2,FOXP3
    transcription factor activity, sequence-specific DNA binding ZNF134,NR2F5,ZFP110,HOXA5A,EGR2A,ESR1,ZFP146,HOXB5A,NR2F1A,MYCN
    sequence-specific DNA binding HLFA,HOXC10A,PAX3,FOXF2,FOXG1D,SALL4,PBX3B,HOXD1,PBX4,LHX1A
    protein binding PYDC1,SLC39A7,FGA,FRMD6,LUC7L,TNIP1,SLC25A46,TRAPPC2L,NUDC,TEX11
    transcription regulatory region DNA binding TBP,SALL1A,CBX4,FOXC1,SMARCA2,CARM1,HIVEP2A,KLF15,HOXA13,CDK5RAP2

    Interacting Protein

    SOX7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX7.

    GLRX3;Dlg4;SMAD7;SMAD5

    Resources

    Research Area

    Early Endodermal Lineage Markers
    Pluripotent Stem Cell Transcription Factors
    Endodermal Lineage Markers

    References

    • Li, B; Ge, ZP; et al. Decreased Expression of SOX7 is Correlated with Poor Prognosis in Lung Adenocarcinoma Patients. PATHOLOGY & ONCOLOGY RESEARCH 18:1039-1045(2012).
    • Kyuno, J; Masse, K; et al. A functional screen for genes involved in Xenopus pronephros development. MECHANISMS OF DEVELOPMENT 125:571-586(2008).

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