SOX1
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Official Full Name
SRY (sex determining region Y)-box 1 -
Overview
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008] -
Synonyms
SOX1;SRY (sex determining region Y)-box 1;transcription factor SOX-1;SRY-related HMG-box gene 1
Recombinant Proteins
- Chicken
- Human
- Silurana tropicalis
- Mouse
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- N-His&C-Myc
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOX1-5905C | Recombinant Chicken SOX1 | Mammalian Cell | Chicken | His |
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| SOX1-1566HCL | Recombinant Human SOX1 293 Cell Lysate | HEK293 | Human | Non |
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| SOX1-1537HFL | Recombinant Full Length Human SOX1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| SOX1-2072H | Recombinant Human SOX1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SOX1-2072H-B | Recombinant Human SOX1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SOX1-4322C | Recombinant Chicken SOX1 protein, His&Myc-tagged | E.coli | Chicken | N-His&C-Myc | 1-373aa |
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| sox1-5944S | Recombinant Silurana tropicalis sox1 protein, His&His-tagged | E.coli | Silurana tropicalis | His | 1-401aa |
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| Sox1-6048M | Recombinant Mouse Sox1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
SOX1 involved in several pathways and played different roles in them. We selected most pathways SOX1 participated on our site, such as Cardiac Progenitor Differentiation,Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt Signaling Pathway NetPath | TAX1BP3,SALL1,BRD7,TCF4,TFAP2A,PAX2,BCL9,NR5A1,MARK2,MTAP1B |
| Cardiac Progenitor Differentiation | SIRPA,TBX20,NOG,LIN28A,T,LIN28B,NIPAL1,IRX4,NKX2,ROR2 |
Protein Function
SOX1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX1 itself. We selected most functions SOX1 had, and list some proteins which have the same functions with SOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter sequence-specific DNA binding | THRAP3,GATA3,NRIP1,PROX1,SOHLH2,KLF10,SP1,MEOX1,NR4A3,NR1D2 |
| transcription factor activity, sequence-specific DNA binding | LCOR,DLX3,SPIB,RARAB,ELK4,HEYL,FLI1,SALL3B,OTX1B,LBX1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HELT,MZF1,TBX3,T,MSX2,ETS2,EHF,CUX2,IFI203,CRX |
| DNA binding | SEBOX,PALB2,LASS4,PRRX1A,PPARG,TRIM26,PAX8,NKX3.3,HIST1H2BO,HELZ2 |
| protein binding | ANK1,SCARB1,TMEM8A,TRAPPC10,ZCCHC10,LCORL,USP2,ADRB1,ZNF26,NCF2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ELK3,DLX5,NEUROG3,FOXJ1,ATF2,GMEB1,EBF1,ONECUT1,MYBL1,CARF |
Interacting Protein
SOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX1.
STAT3
Resources
Research Area
Early Ectodermal Lineage MarkersNeural Stem Cell Transcription Factors
Neural Stem Cell Markers
Pluripotent Stem Cell Transcription Factors
Ectodermal Lineage Markers
Neural Progenitor Cell Markers
Related Services
Related Products
References
- Horta, ES; Lennon, VA; et al. Neural Autoantibody Clusters Aid Diagnosis of Cancer. CLINICAL CANCER RESEARCH 20:3862-3869(2014).
- Evoli, A; Liguori, R; et al. Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management. NEUROLOGICAL SCIENCES 35:515-520(2014).
