SNX4
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Official Full Name
sorting nexin 4 -
Overview
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. -
Synonyms
SNX4;sorting nexin 4;sorting nexin-4;ATG24B;SNX 4;SNX4_HUMAN;OTTHUMP00000215866
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SNX4-2864H | Recombinant Human SNX4, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| SNX4-15735M | Recombinant Mouse SNX4 Protein | Mammalian Cell | Mouse | His |
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| SNX4-2267Z | Recombinant Zebrafish SNX4 | Mammalian Cell | Zebrafish | His |
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| SNX4-31429TH | Recombinant Human SNX4, His-tagged | E.coli | Human | His | Full L. 1-450 a.a. |
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| SNX4-1663HCL | Recombinant Human SNX4 cell lysate | Human | Non |
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| SNX4-2323H | Recombinant Human SNX4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Snx4-6035M | Recombinant Mouse Snx4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SNX4-8559M | Recombinant Mouse SNX4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SNX4-8559M-B | Recombinant Mouse SNX4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SNX4 involved in several pathways and played different roles in them. We selected most pathways SNX4 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | STAMBPA,SH3GL3A,PML,VPS4A,HSPA6,EPS15,RABEP1,HSPA1L,RHOA,WWP1 |
Protein Function
SNX4 has several biochemical functions, for example, epidermal growth factor receptor binding,insulin receptor binding,leptin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX4 itself. We selected most functions SNX4 had, and list some proteins which have the same functions with SNX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferrin receptor binding | SNX1,Trf,HFE2,HFE,RGMA,CD81,SNX2,TF |
| epidermal growth factor receptor binding | LINGO1B,LINGO1,HBEGFA,AGR2,VAV3,TNK2,AREG,EFEMP1,MS4A1,ATXN2 |
| phosphatidylinositol binding | HIP1,MYO1E,TULP4,SH3PXD2AA,NOXO1,PIK3C2A,MITD1,SH3PXD2A,CCDC88A,SNX9A |
| insulin receptor binding | IRS1,FRS3,SNX1,DOK7,IGF2,DOK4,SLC2A2,IGF1R,PDPK1,INSL3 |
| protein binding | KL,KIF5B,CDKAL1,ARHGEF10,APEX1,DNASE1,CAV3,STX10,UBA52,SPANXC |
| leptin receptor binding | SNX2,SNX1 |
Interacting Protein
SNX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX4.
MAGEA6;ARL6IP1;BIN1;Bin1;SNX30;SNX7;SUPT5H;brrf1_ebvg;HIVEP1
Resources
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References
- Ghai, R; Tello-Lafoz, M; et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. JOURNAL OF CELL SCIENCE 128:553-565(2015).
- Tseng, HY; Thorausch, N; et al. Sorting Nexin 31 Binds Multiple beta Integrin Cytoplasmic Domains and Regulates beta 1 Integrin Surface Levels and Stability. JOURNAL OF MOLECULAR BIOLOGY 426:3180-3194(2014).
