SMPD3
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Official Full Name
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -
Overview
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. -
Synonyms
SMPD3;sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II);NSMASE2;sphingomyelin phosphodiesterase 3;nSMase-2;neutral sphingomyelinase 2;neutral sphingomyelinase II
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- HEK293T
- His
- Myc&DDK
- Non
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
SMPD3 involved in several pathways and played different roles in them. We selected most pathways SMPD3 participated on our site, such as Sphingolipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | LASS1,SGMS2,GLB1,UGT8,CERS5,SPTLC3,GBA2,PPAP2CB,SGPL1,VAPB |
| Metabolic pathways | MGAT5,UROC1,HPD,AMDHD1,LPIN3,XYLB,GCNT4,SHMT2,DSE,HGD |
Protein Function
SMPD3 has several biochemical functions, for example, metal ion binding,sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD3 itself. We selected most functions SMPD3 had, and list some proteins which have the same functions with SMPD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingomyelin phosphodiesterase activity | ENPP7,SMPD1,SMPD2,SMPD4,SMPDL3A,SMPD2A,SMPD5,SMPDL3B |
| metal ion binding | EYA4,ZFR,GALNT14,DZIP1L,ZNF224,MMP13A,ZDHHC18A,FRRS1,AMDHD2,ZNF404 |
Interacting Protein
SMPD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD3.
GDF9;XRCC6;CRMP1;SETDB1;RBM48;RIF1;COPS6;VOPP1;MED31;PLEKHM1
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