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SLC6A5

Official Full Name

solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Overview

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane;glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This;protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic;synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by;exaggerated startle responses and neonatal apnea.
Synonyms

SLC6A5; solute carrier family 6 (neurotransmitter transporter, glycine), member 5; NET1; sodium- and chloride-dependent glycine transporter 2; GLYT2; Glycine transporter; Glycine transporter type 2; SC6AC5; SLC6A5 solute carrier family 6 neurotransmitter transporter, glycine member 5; Slc6a9; Sodium and chloride dependent glycine transporter 2; Solute carrier family 6 member 5; Solute carrier family 6 neurotransmitter transporter glycine member 5; OTTHUMP00000231736; GLYT-2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Zebrafish

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
Fc
Avi
Flag
Strep
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC6A5-118H	Recombinant Human SLC6A5 protein, GST-tagged	Wheat Germ	GST	294-393	Inquiry
Human	SLC6A5-683H	Recombinant Human SLC6A5	Mammalian Cell	His		Inquiry
Human	SLC6A5-1704HCL	Recombinant Human SLC6A5 293 Cell Lysate	HEK293	Non		Inquiry
Human	SLC6A5-1207H	Recombinant Human SLC6A5 Protein (D2-C797), 8×His-Strep, Flag tagged	Insect Cell	His&Flag&Strep	D2-C797	Inquiry
Human	SLC6A5-4083H	Recombinant Human SLC6A5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	SLC6A5-4083H-B	Recombinant Human SLC6A5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SLC6A5-2951H	Recombinant Human SLC6A5 protein, His-tagged	E.coli	His	1-200 aa	$319 / 25μg
Zebrafish	SLC6A5-1947Z	Recombinant Zebrafish SLC6A5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SLC6A5 involved in several pathways and played different roles in them. We selected most pathways SLC6A5 participated on our site, such as Na+/Cl- dependent neurotransmitter transporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Na+/Cl- dependent neurotransmitter transporters	SLC6A7;SLC6A5;SLC6A2;SLC6A20B;SLC6A1A;SLC6A12;SLC6A1B;SLC6A11;SLC6A20A
SLC-mediated transmembrane transport	SLC13A1;SLC20A1;SLC41A1;SLC26A3.2;SLC30A3;SLC29A3;SLC5A11;MATE4;SLC20A2
Transmembrane transport of small molecules	SLC12A1;SLC2A13B;SLC7A8A;CLCN6;MRS2;APOD;SLC5A6B;CLCN2;FXYD3
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	SLC5A9;SLC30A2;SLC13A5A;SLC6A6A;SLC6A7;SLC22A16;SLC30A1A;RHCG;SLC10A6

SLC6A5 has several biochemical functions, for example, glycine:sodium symporter activity, neurotransmitter:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A5 itself. We selected most functions SLC6A5 had, and list some proteins which have the same functions with SLC6A5. You can find most of the proteins on our site.

Function	Related Protein
glycine:sodium symporter activity	SLC6A5;SLC6A9
neurotransmitter:sodium symporter activity	SLC6A19B;SLC6A20;SLC6A4A;SLC6A20A;SLC6A12;SLC6A6;SLC6A7;SLC6A18;SLC6A9

SLC6A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A5.

Research Area

Sherman, D; Worrell, JW; et al. Optogenetic perturbation of preBotzinger complex inhibitory neurons modulates respiratory pattern. NATURE NEUROSCIENCE 18:408-414(2015).

Arribas-Gonzalez, E; de Juan-Sanz, J; et al. Molecular Basis of the Dominant Negative Effect of a Glycine Transporter 2 Mutation Associated with Hyperekplexia. JOURNAL OF BIOLOGICAL CHEMISTRY 290:2150-2165(2015).