SLC18A2
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Official Full Name
solute carrier family 18 (vesicular monoamine), member 2 -
Overview
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton;gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity;of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is;a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 (PubMed;7905859)). See also SLC18A1 (MIM 193002). -
Synonyms
SLC18A2;solute carrier family 18 (vesicular monoamine), member 2;VMAT2;synaptic vesicular amine transporter;SVAT;SVMT;monoamine transporter;vesicular amine transporter 2;vesicle monoamine/H+ antiporter;solute carrier family 18 member 2;vesicle m
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- Non
- His
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
SLC18A2 involved in several pathways and played different roles in them. We selected most pathways SLC18A2 participated on our site, such as Synaptic vesicle cycle,Serotonergic synapse,Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC18A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synaptic vesicle cycle | ATP6V0A1,STX1A,ATP6V1B2,STX2,ATP6V0D2,ATP6V1E2,SYT1,CPLX4,SLC17A6,UNC13C |
| Parkinsons disease | NDUFB6,NDUFS7,NDUFA4L2,NDUFC1,NDUFB10,PARK2,SEPT5,PRKACG,GNAI2,SDHB |
| Serotonergic synapse | GNG7,KCND2,PLA2G4A,KCNN2,GNG3,GABRB2,HTR5A,GABRB3,PRKCB,CYP2C37 |
| Alcoholism | HIST2H3C1,MAOB,HDAC4,HIST1H2BL,DRD1,CALM2,GNG2,HIST1H2AI,HDAC7,NTRK2 |
| Dopaminergic synapse | MAPK12,GNG8,GNG4,KCNJ3,MAPK8,ITPR3,GNG5,CREB3L3,PPP2R2A,GNB4 |
| Cocaine addiction | CREB3L3,DLG4,CREB3,PRKACG,DRD1,GRIN3B,NFKB1,DRD2,GNAI2,GRIA2 |
Protein Function
SLC18A2 has several biochemical functions, for example, monoamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC18A2 itself. We selected most functions SLC18A2 had, and list some proteins which have the same functions with SLC18A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monoamine transmembrane transporter activity | SLC6A2,SLC6A4,SLC29A4,SLC22A1,SLC18A1,SLC6A3 |
Interacting Protein
SLC18A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC18A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC18A2.
Resources
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References
- Ashe, KM; Chiu, WL; et al. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. NEUROENDOCRINOLOGY LETTERS 32:253-258(2011).
