SLC18A1
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Official Full Name
solute carrier family 18 (vesicular monoamine), member 1 -
Overview
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient;maintained across the vesicular membrane. Its proper function is essential to the correct activity of the;monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site;of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 (PubMed 7905859)). See also;SLC18A2 (MIM 193001). -
Synonyms
SLC18A1;solute carrier family 18 (vesicular monoamine), member 1;VAT1, VMAT1;chromaffin granule amine transporter;CGAT;4832416I10Rik;Adrenal chromaffin granule amine transporter;MGC28683;MGC37299;Solute carrier family 18 member 1;VAT 1;VAT1;Vesicular amine transporter 1;VMAT 1;VMAT1_HUMAN;OTTHUMP00000122508;OTTHUMP00000224712;OTTHUMP00000224713;OTTHUMP00000224714;OTTHUMP00000237226;VMAT1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC18A1-2702H | Recombinant Human SLC18A1, GST-tagged | E.coli | Human | GST | 43-138aa | |
| SLC18A1-29829TH | Recombinant Human SLC18A1 | Wheat Germ | Human | Non | 494 amino acids |
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| SLC18A1-371H | Recombinant Human SLC18A1 | Mammalian Cells | Human | His |
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| SLC18A1-4067H | Recombinant Human SLC18A1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SLC18A1-4067H-B | Recombinant Human SLC18A1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SLC18A1-487HF | Recombinant Full Length Human SLC18A1 Protein | In Vitro Cell Free System | Human | Full L. 494 amino acids |
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Involved Pathway
SLC18A1 involved in several pathways and played different roles in them. We selected most pathways SLC18A1 participated on our site, such as Synaptic vesicle cycle,Serotonergic synapse,Dopaminergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC18A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | UBE1Y1,HTRA2,GNAI1,NDUFB10,VDAC3,SLC6A3,NDUFA4L2,SDHA,NDUFV2,PINK1 |
| Cocaine addiction | SLC6A3,GRIA2,PRKACA,DRD2,NFKB1,GRIN1,DRD1A,CREB3,GRIN2B,GRIN3A |
| Dopaminergic synapse | GRIN2B,CREB3L3,PPP2R2D,PPP2R5C,GNAS,GRIA1,PPP3CB,CAMK2B,GRIA2,GNAO1 |
| Serotonergic synapse | HTR6,KRAS,GNB2,ALOX12E,GNB3,HTR1F,SLC6A4,MAP2K1,ARAF,GNG8 |
| Synaptic vesicle cycle | ATP6V1F,ATP6V0E,CPLX3,UNC13A,ATP6V1E1,ATP6V1B2,ATP6V1C1,STXBP1,ATP6V0B,CPLX4 |
| Alcoholism | HIST3H2BB-PS,HDAC7,HIST1H2AC,SHC3,GNAI2,KRAS,HIST1H2AK,GRIN2A,GM14476,HIST1H2BC |
Protein Function
SLC18A1 has several biochemical functions, for example, drug transmembrane transporter activity,enzyme binding,monoamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC18A1 itself. We selected most functions SLC18A1 had, and list some proteins which have the same functions with SLC18A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | TSPAN17,PAWR,ESR2,MARCH6,UGT1A9,KRT79,BLZF1,YWHAB,UGT1A6,PDCD2 |
| monoamine transmembrane transporter activity | SLC22A1,SLC6A3,SLC29A4,SLC6A4,SLC18A2,SLC6A2 |
| serotonin transmembrane transporter activity | SLC6A4,SLC6A4B,SLC6A4A |
| drug transmembrane transporter activity | SLC47A1,SLC47A2,Abcb1b,SLC22A18,ABCG2D,SLC17A3,ABCG3,EBP,SLC22A5,SLC18A3A |
Interacting Protein
SLC18A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC18A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC18A1.
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References
- Ashe, KM; Chiu, WL; et al. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. NEUROENDOCRINOLOGY LETTERS 32:253-258(2011).
