SIX5
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Official Full Name
SIX homeobox 5 -
Overview
The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. -
Synonyms
SIX5;SIX homeobox 5;DMAHP, sine oculis homeobox (Drosophila) homolog 5 , sine oculis homeobox homolog 5 (Drosophila);homeobox protein SIX5;sine oculis homeobox homolog 5;DM locus-associated homeodomain protein;dystrophia myotonica-associated homeo
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIX5-15165M | Recombinant Mouse SIX5 Protein | Mammalian Cell | Mouse | His |
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| SIX5-4210R | Recombinant Rhesus monkey SIX5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SIX5-9241Z | Recombinant Zebrafish SIX5 | Mammalian Cell | Zebrafish | His |
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| SIX5-1822HCL | Recombinant Human SIX5 293 Cell Lysate | HEK293 | Human | Non |
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| SIX5-4026R | Recombinant Rhesus Macaque SIX5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SIX5-4026R-B | Recombinant Rhesus Macaque SIX5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SIX5-5036H | Recombinant Human SIX5 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Six5-5890M | Recombinant Mouse Six5 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SIX5-8189M | Recombinant Mouse SIX5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SIX5-8189M-B | Recombinant Mouse SIX5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SIX5 involved in several pathways and played different roles in them. We selected most pathways SIX5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SIX5 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX5 itself. We selected most functions SIX5 had, and list some proteins which have the same functions with SIX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMARCA4,PSMA6,UBE2K,POLR2A,CD151,PEG10,PRKCI,MMP2,CAML,TADA3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HNRNPK,GLI2,HOXA10,HAND1,ELF1,KCNA3,CHD7,MITFA,NKX6-1,AKNA |
Interacting Protein
SIX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX5.
ATXN1;q81y32_bacan;hemC;degQ
Resources
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References
- Pham, YCN; Man, NT; et al. Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies. JOURNAL OF CELLULAR BIOCHEMISTRY 95:990-1001(2005).
- Man, NT; Pham, YCN; et al. Nuclear localization of the myotonic dystrophy-associated Six5 protein using a new panel of monoclonal antibodies. JOURNAL OF THE NEUROLOGICAL SCIENCES 199:S5-S5(2002).
- Lam, LT; Pham, YCN; et al. Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. HUMAN MOLECULAR GENETICS 9:2167-2173(2000).
- Ohto, H; Takizawa, T; et al. Tissue and developmental distribution of Six family gene products. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 42:141-148(1998).
