SIAH1
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Official Full Name
seven in absentia homolog 1 (Drosophila) -
Overview
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. -
Synonyms
SIAH1;seven in absentia homolog 1 (Drosophila);E3 ubiquitin-protein ligase SIAH1;hSIAH1;HUMSIAH;Seven in absentia homolog 1;SIAH 1;Siah 1a;Ubiquitin ligase SIAH1;siah-1a;OTTHUMP00000164188;OTTHUMP00000164189;SIAH1A
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIAH1-2668H | Recombinant Human SIAH1, GST-tagged | E.coli | Human | GST | 1-282aa | |
| SIAH1-4200R | Recombinant Rhesus monkey SIAH1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SIAH1-9929Z | Recombinant Zebrafish SIAH1 | Mammalian Cells | Zebrafish | His |
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| SIAH1-1851HCL | Recombinant Human SIAH1 293 Cell Lysate | HEK293 | Human | Non |
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| SIAH1-4016R | Recombinant Rhesus Macaque SIAH1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| SIAH1-4016R-B | Recombinant Rhesus Macaque SIAH1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SIAH1-4629H | Recombinant Human SIAH1 protein, GST-tagged | E.coli | Human | GST | 1-313aa |
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Involved Pathway
SIAH1 involved in several pathways and played different roles in them. We selected most pathways SIAH1 participated on our site, such as p signaling pathway,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | EI24,PIDD1,GADD45AB,SIAH1A,FAS,CD82A,PPM1DA,CCNG1,CCNB3,ZMAT3 |
| Ubiquitin mediated proteolysis | UBE2D4,UBE2R2,UBE2W,VHL,CUL1B,UBE3C,KLHL9,RCHY1,UBA1,UBE2Q1 |
| Wnt signaling pathway | PLCB4,PRKCG,PPP3R2,WNT2,CER1,AXIN2,WIF1,WNT16,RAC3A,TRP53 |
Protein Function
SIAH1 has several biochemical functions, for example, identical protein binding,ligase activity,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH1 itself. We selected most functions SIAH1 had, and list some proteins which have the same functions with SIAH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | XRCC4,NCL,FOXN3,PICK1,VTA1,SHANK2,ATP2A2,TRIM3,MID1IP1,PRDX3 |
| zinc ion binding | TRIM42,SPG7,SETDB1,BTR22,TRIM54,TRIM39,AMFR,PPARG,CPA1,PAPPA |
| protein binding | KIF23,SNRPC,IL11,RXRG,TRPC5,FAM108A1,MME,FOXP3,PRKD1,RRM1 |
| ubiquitin-protein transferase activity | RNF181,UBE2R2,LTN1,MARCH6,FBXL6,UBE2O,BIRC5A,TRIM23,FBXO7,UBE2E1 |
| ligase activity | BRAP,DTX4,TRIM4,SMURF2,PCXB,RNF2,GLULC,TRIM27,RNF5,CBLC |
| identical protein binding | VCP,PFKM,SUN2,UHRF1,BRAP,EDC3,FHL2,RIPK3,IL12B,CUBN |
| ubiquitin protein ligase activity | UBE2O,TRIM32,ZNRF2,CCNB1IP1,RNF144AA,ARIH1,UBE2NA,RAG1,UBE2T,RAG2 |
Interacting Protein
SIAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH1.
PHC2;PUF60;EEF1D;UBE2K
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