SHOX
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Official Full Name
short stature homeobox -
Overview
This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
SHOX;short stature homeobox;short stature homeobox protein;GCFX;PHOG;SHOXY;SS;Growth control factor, X linked;Homo sapiens shox gene, alternatively spliced products, complete cds;Pseudoautosomal homeobox containing osteogenic;Pseudoautosomal homeobox containing osteogenic protein;Short stature homeobox containing protein;Turner syndrome;growth control factor, X-linked;short stature homeobox-containing protein;pseudoautosomal homeobox-containing osteogenic protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHOX-2664H | Recombinant Human SHOX, GST-tagged | E.coli | Human | GST | 17-110aa | |
| SHOX-3557C | Recombinant Chicken SHOX | Mammalian Cell | Chicken | His |
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| SHOX-6725Z | Recombinant Zebrafish SHOX | Mammalian Cell | Zebrafish | His |
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| SHOX-1603HCL | Recombinant Human SHOX cell lysate | Human | Non |
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| SHOX-2462H | Recombinant Human SHOX protein(11-160 aa), C-His-tagged | E.coli | Human | His | 11-160 aa |
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| SHOX-5586H | Recombinant Human SHOX Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
SHOX involved in several pathways and played different roles in them. We selected most pathways SHOX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SHOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SHOX has several biochemical functions, for example, protein binding,sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHOX itself. We selected most functions SHOX had, and list some proteins which have the same functions with SHOX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TICAM2,NMU,RPRM,RFC3,NOD1,EXOSC10,LMO1,SEC14L4,FOXG1,HMG20A |
| sequence-specific DNA binding | POU2F1,FOXH1,PAX7,NKX1.2LB,EDF1,ELF2,LBX1A,PNX,PRRX1A,HOXC1A |
| transcription factor activity, sequence-specific DNA binding | MECOM,ZFP551,ZFP354C,GRHL2B,POU5F1,SOX6,RFX2,TFAM,REST,ZNF227 |
Interacting Protein
SHOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHOX here. Most of them are supplied by our site. Hope this information will be useful for your research of SHOX.
SOX5;SOX6;Sox5;Sox6
Resources
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References
- Binder, G; Ranke, MB; et al. Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 88:4891-4896(2003).
