SFRP1
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Official Full Name
secreted frizzled-related protein 1 -
Overview
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] -
Synonyms
SFRP1;secreted frizzled-related protein 1;FRP;FRP1;FrzA;FRP-1;SARP2;SARP-2;sFRP-1;secreted apoptosis-related protein 2
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Chicken
- Human Cell
- E.coli
- HEK293
- Mammalian cells
- HeLa
- Mammalian Cell
- CHO
- His
- Non
- Fc
- His&Fc&Avi
Involved Pathway
SFRP1 involved in several pathways and played different roles in them. We selected most pathways SFRP1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | WIF1,ROCK2,PPP3R1,RUVBL1,FZD7B,FZD3,MMP7,TP53,RHOAB,WNT11B |
Protein Function
SFRP1 has several biochemical functions, for example, NOT G-protein coupled receptor activity,NOT Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP1 itself. We selected most functions SFRP1 had, and list some proteins which have the same functions with SFRP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | USP17L2,CTSZ,CTSM,USP45,CTSC,USP27X,PSD,USP51,USP10,BLMH |
| Wnt-protein binding | LRP5L,CTHRC1,ROR1,FZD9,FZD3A,FZD10,PORCN,FZD5,FZD6,SFRP4 |
| frizzled binding | WNT11R,RSPO3,FZD1,WNT10B,WNT9A,WNT7A,WNT2BA,MYOC,WNT11,WNT9B |
| NOT G-protein coupled receptor activity | SFRP2,SFRP1A,LGR6,LGR5,FRZB,SFRP1B,LGR4,SFRP4,SZL |
| drug binding | FASN,MT3,PPP3CA,TYMS,SETD6,PPARD,CHKA,DAAM2,ABP1,P2RX1 |
| identical protein binding | FHL2,MAP3K11,SNCA,CCL3,KHDRBS1,CLDNG,PRPF19,IMPA1,DCTPP1,AMELX |
| protein binding | RIPK1,CAMTA2,OAZ1,CACNA2D1A,TYRO3,UBXN11,APLF,RAB32,RPS20,SPANXA1 |
| heparin binding | PGF,WISP1,FMOD,TENM1,MDK,APP,APOB,KAL1,NRP2,WISP1A |
| NOT Wnt-activated receptor activity | SZL,TSPAN12,SFRP4,SMO,SFRP1A,FRZB,SFRP2,SFRP1B,SETD6 |
Interacting Protein
SFRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFRP1.
FZD6;WNT2;KIAA1522
Resources
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References
- Ghoshal, A; Ghosh, SS; et al. Expression, Purification, and Therapeutic Implications of Recombinant sFRP1. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:2087-2103(2015).
- Whyte, MP; Madson, KL; et al. Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis. JOURNAL OF BONE AND MINERAL RESEARCH 29:2601-2609(2014).
