SERPINA3
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Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -
Overview
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. -
Synonyms
SERPINA3;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3;ACT;AACT;GIG24;GIG25;alpha-1-antichymotrypsin;serpin A3;growth-inhibiting protein 24;growth-inhibiting protein 25;cell growth-inhibiting gene 24/25 protein;serine (or cysteine) proteinase inhibitor, clade A, member 3
Recombinant Proteins
- Human
- Horse
- Mouse
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- Rabbit
- human plasma
- E. coli
- Human Serum
- Normal Human Serum
- His
- His&GST
- Non
- His&Fc&Avi
- GST
- N-His-GST
Involved Pathway
SERPINA3 involved in several pathways and played different roles in them. We selected most pathways SERPINA3 participated on our site, such as Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Selenium Pathway | DIO2,SAA2-SAA4,CRP,PRDX4,SAA4,PRDX3,SELK,SEP15,PRDX2,TXNRD3IT1 |
Protein Function
SERPINA3 has several biochemical functions, for example, DNA binding,protein binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA3 itself. We selected most functions SERPINA3 had, and list some proteins which have the same functions with SERPINA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRIB3,MAGEE1,LIMD1,GAGE8,FAM20A,CYTH1,GZMB,PSEN1,CDK5R1,ESR2 |
| DNA binding | ZNF41,FOXN4,ZNF230,KCNH7,ISL2,ZNF184,TADA2B,ZNF434,ZBTB41,ETV5A |
| serine-type endopeptidase inhibitor activity | SERPINB13,SPINT1B,WFDC2,FURIN,CD109,WFDC5,SERPINB1L1,SERPINA3M,SERPINA1,WFDC6 |
Interacting Protein
SERPINA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA3.
DNAJC1;KLK3;ABCC5;ADH1B;NFKB1;LMNB1;SGCD;ZNRD1;LAMC3;ATP6V1A
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References
- Jennings, P; Crean, D; et al. Interleukin-19 as a translational indicator of renal injury. ARCHIVES OF TOXICOLOGY 89:101-106(2015).
- Amico, AD; Ragusa, R; et al. Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
